摘要
Abstract
Objective To explore the therapeutic effect of Xipayi mouth rinse combined with tinidazole on patients with periodontitis,and its impacts on chewing function and inflammatory response.Methods A total of 102 patients with periodontitis accepted by the hospital from August 2020 to August 2022 were randomly separated into a combined group of 51 cases and a reference group of 51 cases.Reference group was treated with tinidazole,while combined group was treated with tinidazole and Xipayi mouth rinse.The two groups were compared in terms of total effective rate,periodontal related indicators,Barthel chewing scale scores,levels of inflammatory factors,and incidence of adverse events after treatment.Results After treatment,the total effective rate of combined group(92.16%)was obviously increased compared to reference group(76.47%)(P＜0.05).The periodontal pocket depth(PD),gingival index(GI),and plaque index(PLI)of combined group were obviously lower than those of reference group(P＜0.05).The Barthel score of combined group was obviously higher than that of reference group(P＜0.05);the levels of interleukin-6(IL-6),matrix metalloproteinase-8(MMP-8),and monocyte chemotactic protein-1(MCP-1)in combined group were obviously lower than those in reference group(P＜0.05).There was no obvious difference in the incidence of adverse events between the two groups(P＞0.05).Conclusion The combination of Xipayi mouth rinse and tinidazole can effectively improve the chewing function of patients with periodontitis,regulate the levels of inflammatory factors,and achieve ideal results.The clinical application value is high.关键词
牙周炎/西帕依固龈液/替硝唑/咀嚼功能/炎症因子Key words
periodontitis/xipayi mouth rinse/tinidazole/chewing function/inflammation factors分类
医药卫生
