中国实验动物学报2025，Vol.33Issue(1)：99-107,9.DOI:10.3969/j.issn.1005-4847.2025.01.010
PDO异种移植模型在肿瘤精准化治疗研究中的应用进展
Progress in application of patient-derived organoid xenograft model in cancer precision therapy
摘要
Abstract
Precision therapy has become an important approach in modern medicine,with the goal of providing individualized treatment according to the characteristics of individual patients.The successful development of precision medicine depends on the application of preclinical cancer models.Patient-derived organoid(PDO)xenograft models display characteristics of both PDO models and in vivo patient-derived tumor xenograft models.This type of model can not only maintain the heterogeneity of the original tumor,but also has additional advantages,such as large-scale cultivation,high-throughput drug screening in vitro and drug sensitivity testing in vivo.It is an innovative,precise preclinical disease model.In this review,we summarize the basic characteristics of the PDO xenograft model,analyze its construction method and influencing factors,further discuss its application in precision therapy,with the aim of providing a reliable preclinical experimental tool for individualized cancer treatment.关键词
病患来源的肿瘤类器官/异种移植/精准治疗/肿瘤异质性/药物敏感性Key words
patient-derived tumor organoids/xenograft/precision medicine/tumor heterogeneity/drug susceptibility分类
生物学引用本文复制引用
邢燕子,赵菊梅,师长宏..PDO异种移植模型在肿瘤精准化治疗研究中的应用进展[J].中国实验动物学报,2025,33(1):99-107,9.基金项目
国家自然科学基金(32070532,32270566).Funded by the National Natural Science Foundation of China(32070532,32270566). （32070532,32270566）
