中国实验动物学报2025，Vol.33Issue(1)：108-116,9.DOI:10.3969/j.issn.1005-4847.2025.01.011
罗伊氏乳杆菌降胆固醇的作用与机制研究进展
Progress in studies on the action and mechanism of Lactobacillus reuteri in lowering cholesterol
摘要
Abstract
Cardiovascular diseases that develop from hypercholesterolemia-induced atherosclerosis have emerged as a significant threat to human health.Recently,probiotics exhibiting cholesterol-lowering properties have emerged as a prominent area of research.Numerous studies have demonstrated that Lactobacillus reuteri can effectively reduce endogenous cholesterol synthesis,regulate cholesterol transport,and promote cholesterol degradation by modulating the expression of key genes,such as sterol-regulatory element binding protein 2,3-hydroxy-3-methyl-glutaryl coenzyme A reductase,and cholesterol 7 alpha-hydroxylase,in both the liver and intestinal epithelial cells of the host.This leads to a notable decrease in total cholesterol and low-density lipoprotein cholesterol levels in the host serum.The present paper offers a comprehensive overview of the underlying mechanisms responsible for the cholesterol-lowering effects exerted by L.reuteri,aiming to provide valuable insights into the treatment of hypercholesterolemia and the development of probiotics with cholesterol-lowering properties.关键词
益生菌/罗伊氏乳杆菌/降胆固醇/作用与机制Key words
probiotics/Lactobacillus reuteri/cholesterol-lowering/action and mechanisms分类
生物学引用本文复制引用
安昊杰,高江梅,钟秀玲,颜青,龙程,饶军华..罗伊氏乳杆菌降胆固醇的作用与机制研究进展[J].中国实验动物学报,2025,33(1):108-116,9.基金项目
国家自然科学基金(82200966),广东省科学院科技发展专项(2022GDASZH-2022010110).Funded by National Natural Science Foundation of China(82200966),GDAS Special Project of Science and Technology Development(2022GDASZH-2022010110). （82200966）
