中国实验动物学报2025，Vol.33Issue(1)：117-126,10.DOI:10.3969/j.issn.1005-4847.2025.01.012
肌少症小鼠模型运动功能测评方法的研究进展
Research progress of motor function evaluation methods in animal models of sarcopenia
摘要
Abstract
Sarcopenia is an age-related skeletal muscle degenerative disease.Physiologically aging mice are the most commonly used animal model for studying sarcopenia.As sarcopenia is characterized by decreased skeletal muscle mass and reduced muscle strength,exercise performance as a reflection of muscle function is widely used to evaluate sarcopenia.Methods of evaluating the motor function of sarcopenia mouse models are generally designed based on muscle endurance,muscle strength,coordination,and balance.The method include tests such as treadmill exhaustion,voluntary wheel use,grip strength,horse grid,bars and balance beam tests.By collating recent publications,we have systematically summarized the method used for evaluating motor function,including the tests'principles,procedures,evaluation indexes,advantages,and disadvantages.We then propose an operational program for evaluating the sarcopenia phenotype,which will be of help to researchers wishing to choose evaluation method appropriate to their specific research purposes.Further innovative technology for assessing motor function that could be instructive in the evaluation of skeletal muscle function and diagnosis of sarcopenia is summarized.关键词
肌少症/小鼠/运动功能测评Key words
sarcopenia/mice/motor function assessment分类
生物学引用本文复制引用
杨森,张勇,周志雄,曾平..肌少症小鼠模型运动功能测评方法的研究进展[J].中国实验动物学报,2025,33(1):117-126,10.基金项目
中央高水平医院临床科研专项(2022-PUMCH-B-133),国家重点研发项目资助(2022YFA0806002).Funded by the Grants of the National High Level Hospital Clinical Research Funding(2022-PUMCH-B-133),the National Key R&D Program of China(2022YFA0806002). （2022-PUMCH-B-133）
