中国实验动物学报2025，Vol.33Issue(1)：127-140,14.DOI:10.3969/j.issn.1005-4847.2025.01.013
类风湿性关节炎实验模型研究进展
Advances in experimental models of rheumatoid arthritis
摘要
Abstract
Rheumatoid arthritis(RA)is a chronic autoimmune disease that significantly impacts joints.Experimental models are crucial tools for studying the pathogenesis and pharmaco-toxicological mechanisms of RA and screening RA drugs.Commonly used experimental RA models include animal models and in vitro models.With advancements in biotechnology and biomaterials,experimental RA models have evolved from induced and 2D in vitro models to spontaneous gene modification and 3D in vitro models.Moreover,some progress has been made in the study of traditional Chinese medicine disease and syndrome combination models.This paper summarizes the research progress made in the modeling,monitoring,and evaluation of experimental RA models to provide a reference for related research.关键词
类风湿性关节炎/动物模型/体外模型/诱导性模型Key words
rheumatoid arthritis/animal model/in vitro model/inducible model分类
生物科学引用本文复制引用
王俊伟,耿兴超,李伟..类风湿性关节炎实验模型研究进展[J].中国实验动物学报,2025,33(1):127-140,14.基金项目
药品监管科学全国重点实验室项目(2023SKLDRS0126).Funded by National Key Laboratory of Drug Regulatory Science(2023SKLDRS0126). （2023SKLDRS0126）
