中国实用儿科杂志2025，Vol.40Issue(2)：126-135,10.DOI:10.19538/j.ek2025020609
尿N-乙酰β-D-氨基葡萄糖苷酶、血清胱抑素C在儿童单纯性肥胖肾脏早期损害的临床价值
Clinical value of urinary NAG and serum Cys-C in early renal damage of simple obesity in children
摘要
Abstract
Objective To investigate the clinical value of urine N-acetyl-β-D-glucosaminidase(uNAG)and serum cystatin-C(Cys-C)in the assessment of early renal damage in children with simple obesity.Methods A total of 302 children with simple obesity were selected,who were diagnosed in the Department of Endocrinology,Genetics and Metabolism of Children's Hospital of Soochow University from October 2021 to January 2024,and 53 children of similar age in the same period were selected as the normal control group.The clinical data of the two groups were collected,including basic data,blood and urine test results,compare the differences in clinical data of different stages of obesity and normal control group.Analyze the correlation between serum Cys-C,urine NAG,and kidney function.Compare simple obesity group based on their urnie albumin creatine raio(UACR),dividing them into an albuminuria group and a normal albuminuria group.Examine the differences in general clinical data and laboratory parameters between these two subgroups.Multivariate Logistic regression analysis was used to identify the predictors of renal damage.Results There were statistically significant differences in total cholesterol(TC),triglyceride(TG)and triglyceride-glucose index(TyG)between the obese albuminuria group and the obese no-albuminuria group(P＜0.05),and there were significant differences in β2-microglobulin(mALB),uNAG and UACR(P＜0.05).In the obese albuminuria group,uNAG was moderately positively correlated with mALB and UACR,and moderately negatively correlated with β2M.uNAG was an independent influencing factor for early renal damage in children with simple obesity.The area under the ROC curve was the largest in the combined detection of uNAG and serum Cys-C,and the specificity and sensitivity were relatively high.Conclusion The children with simple obesity may have early kidney damage.uNAG is an independent influencing factor for early renal damage in children with simple obesity.The combination of uNAG,uNAG and serum Cys-C has certain value in the evaluation of early renal damage in children with simple obesity.关键词
儿童单纯性肥胖/尿N-乙酰β-D-氨基葡萄糖苷酶/肥胖相关性肾损伤Key words
simple obesity in children/urine n-acetyl-β-D-glucosaminidase/obesity-related renal damage分类
临床医学引用本文复制引用
王晓艳,王莉莉,吴海瑛,华敏,王凤云,谢蓉蓉,陈临琪,陈秀丽,陈婷,孙辉,张丹丹..尿N-乙酰β-D-氨基葡萄糖苷酶、血清胱抑素C在儿童单纯性肥胖肾脏早期损害的临床价值[J].中国实用儿科杂志,2025,40(2):126-135,10.基金项目
苏州市科技发展计划(SKYD2023130) （SKYD2023130）
