中国实用外科杂志2025，Vol.45Issue(2)：181-186,6.DOI:10.19538/j.cjps.issn1005-2208.2025.02.10
槐耳颗粒预防伴有高危复发危险因素肝细胞癌术后复发的临床疗效分析
Clinical efficacy of Huaier granule on postoperative prevention of recurrence in HCC patients with high risk factors of recurrence
摘要
Abstract
Objective To investigate the clinical efficacy of Huaier granule in preventing postoperative recurrence in HCC patients associated with high-risk factors of recurrence.Methods Between January 2019 and January 2022,118 patients who were confirmed with high-risk factors of recurrence by pathological results(combined with microvascular invasion,tumor size ≥ 5 cm,or poor differentiation)in the First Affiliated Hospital of the University of Science and Technology of China(Anhui Provincial Hospital)were retrospectively analyzed.Based on whether they received Huaier granule or no further treatment after HCC resection,patients were divided into the Huaier group(38 cases)and the control group(80 cases).The primary endpoint was 1-year recurrence-free survival(RFS).Propensity score matching(PSM)was used to avoid possible selection bias.Results The median follow-up time was 13(2-40)months.Before PSM,there were significant differences in the proportion of males,positive for Hepatitis B surface antigen(HBsAg),alpha-fetoprotein(AFP)≥400 μg/L,and poor differentiation between the two groups(All P＜0.05).The 1-year RFS rates were 86.8％versus 51.2％(P＜0.001)for the Huaier and control groups,respectively.The Cox proportional hazards model identified the Huaier granule as an independent predictor for recurrence-free survival(RFS)(HR=0.333,95％CI 0.162-0.686,P=0.003).In the propensity model,the baseline variables were well-balanced between the two groups(both P＞0.05).The 1-year RFS rates were 84.6％versus 57.7％(P=0.042)for the Huaier and control groups,respectively.The difference was still statistically significant.Compared with the Huaier group,the control group had a higher incidence of intrahepatic multiple metastases(before PSM:0 vs.15.0％,P=0.028;after PSM:0 vs.23.1％,P=0.023).Conclusion For HCC patients at a high risk of recurrence after radical resection,Huaier granules can significantly improve the 1-year RFS and reduce the incidence of intrahepatic multiple metastases.It is an effective adjuvant therapy to prevent recurrence after HCC resection.关键词
肝细胞癌/槐耳颗粒/术后复发/预防Key words
hepatocellular carcinoma/Huaier granule/postoperative recurrence/prevention分类
医药卫生引用本文复制引用
姜坤元,刘子豪,李靖飞,尹大龙..槐耳颗粒预防伴有高危复发危险因素肝细胞癌术后复发的临床疗效分析[J].中国实用外科杂志,2025,45(2):181-186,6.基金项目
国家自然科学基金项目(No.82172071) （No.82172071）
国家卫生健康委医院管理研究所重点项目(No.YLZLXZ22K004) National Natural Science Foundation of China(No.82172071) （No.YLZLXZ22K004）
Key Project of National Institute of Hospital Administration(No.YLZLXZ22K004) （No.YLZLXZ22K004）
