中国兽医杂志2025，Vol.61Issue(3)：12-21,10.DOI:10.20157/j.cnki.zgsyzz.2025.03.002
芒果苷-莱鲍迪苷A自组装纳米胶束的制备及表征
Preparation and Characterization of Mangiferin-Rebaudioside A Self-Assembled Nanomicelles
摘要
Abstract
To prepare mangiferin(MGF)-rebaudioside A(RebA)self-assembled nanomicelles(MGF-RebA SNM)and evaluate their quality,a high-performance liquid chromatography(HPLC)method was established to measure the MGF content in MGF-RebA SNM.The specificity,precision,repeatability,stability,and recovery of this method were investigated.A single-factor experiment was conducted to study the effects of RebA dosage,MGF dosage,ultrasonic power,ultrasound time,and organic phase ratio on the encapsulation efficiency(EE).Using EE as the response value,the Box-Behnken response surface method observed under transmission electron microscopy was a regular spherical shape.The 6-hour cumulative release rate was 91.43%,significantly better than the MGF raw material(71.40%),indicating that the formation of the micelles improved the in vitro cumulative release of MGF.The results suggest that the prepared MGF-RebA SNM have a high EE,small and uniform particle size,and good in vitro release,providing a useful reference for the development of new MGF formulations.关键词
芒果苷/莱鲍迪苷A/自组装/纳米胶束Key words
mangiferin/rebaudioside A/self-assembled/nanomicelles分类
农业科技引用本文复制引用
牛梦楚,任凌仪,马箐阳,杜倩笙,易丹丹,吴春璇,张思媛,何家康..芒果苷-莱鲍迪苷A自组装纳米胶束的制备及表征[J].中国兽医杂志,2025,61(3):12-21,10.基金项目
广西重点研发计划项目重点专项(桂科AB23026082) （桂科AB23026082）
大学生创新创业训练计划项目(202210593097) （202210593097）
