中国兽医杂志2025，Vol.61Issue(3)：81-85,5.DOI:10.20157/j.cnki.zgsyzz.2025.03.011
氟苯尼考包合微囊的研制
Preparation of Florfenicol Encapsulated Microcapsules
摘要
Abstract
To overcome the poor water solubility,low bioavailability,and inability to be administered with drinking water of florfenicol,this study used florfenicol as the active ingredient and β-cyclodextrin as an excipient.The encapsulation technique using cyclodextrin and spray drying method was employed to develop florfenicol encapsulated microcapsules.The prepared products were subjected to solubility comparison tests,dissolution tests,stability tests,and pharmacokinetic studies.The results showed that florfenicol-β-cyclodextrin encapsulated microcapsules were successfully prepared with a yield of 99.6%,and the dissolution rate reached 93%within 15 minutes.The product exhibited stable quality,and after oral administration,the peak blood concentration was achieved at 1.44 hours,with a peak concentration of 15.32 μg/mL.The findings suggest that the florfenicol product prepared by this method has good water solubility,fast absorption,high blood concentration,and a feasible production process,which has already been industrialized.This method significantly improves the competitiveness of the product in the market.关键词
氟苯尼考/β-环糊精/包合技术Key words
flufenicol/β-cyclodextrin/encapsulation technique分类
畜牧业引用本文复制引用
赵增成,宋士凯,闫遵祥,黄中利,王海挺,郭丽华,刘在青,肖建森,林树乾,衣云鹏,刘月月,殷斌,杨世发,张荣岭..氟苯尼考包合微囊的研制[J].中国兽医杂志,2025,61(3):81-85,5.基金项目
德州市科技型中小企业创新能力提升工程项目(2022TSGC018) （2022TSGC018）
山东省鲁渝科技协作项目(2022LYXZ030) （2022LYXZ030）
