中国兽医杂志2025，Vol.61Issue(3)：102-109,8.DOI:10.20157/j.cnki.zgsyzz.2025.03.014
兽用抗生素纳米递送系统促进口服吸收的研究进展
Research Progress on Veterinary Antibiotic Nano-Delivery Systems to Enhance Oral Absorption
摘要
Abstract
In recent years,significant progress has been made in the application of antibiotic nano-formulations in livestock farming.Traditional oral administration of veterinary medicines offers advantages such as cost-effectiveness and convenience,making it suitable for large-scale farming.However,it also faces challenges such as low solubility,poor permeability,short residence time in the small intestine,and multiple absorption barriers.Nano-delivery systems enhance the solubility and permeability of drugs,enable nano-controlled release,increase transmembrane transport,and overcome oral absorption barriers,significantly improving the effectiveness of oral administration.Current primary nano-delivery systems include nanocrystals,nanoemulsions,liposomes,cyclodextrin complexes,and antimicrobial nanomaterials.The use of these systems not only improves the bioavailability of drugs but also plays an active role in reducing drug residues and environmental pollution.This review discusses the advantages of nano-delivery systems,the main types and characteristics of veterinary antibiotic nano-delivery systems,and provides insights for the development of veterinary antibiotic nano-formulations.关键词
兽药口服给药/抗生素/纳米递送系统/畜禽养殖Key words
oral administration of veterinary drugs/antibiotic/nano-delivery system/livestock farming分类
医药卫生引用本文复制引用
吴炅,张晴,冒玉娟,郭浩宇,崔宇彤,陈竣岚,王坤,于生兰,周闻舞..兽用抗生素纳米递送系统促进口服吸收的研究进展[J].中国兽医杂志,2025,61(3):102-109,8.基金项目
中国药科大学大学生创新创业训练计划项目(202410316179) （202410316179）
泰州市科技项目(TN202315) （TN202315）
江苏农牧科技职业学院校级科研项目(NSF2022ZR04) （NSF2022ZR04）
