中国听力语言康复科学杂志2025，Vol.23Issue(2)：140-144,189,6.DOI:10.3969/j.issn.1672-4933.2025.02.008
铂类药物所致实体肿瘤患儿听力损伤
Acoustic Injury Induced by Platinum in Children with Solid Tumors
摘要
Abstract
Objective To explore the relationship between cisplatin and carboplatin and hearing loss caused by platinum drugs in solid tumors in children.Methods From January 2020 to December 2023,children with solid tumors who used carboplatin and/or cisplatin in the Department of Medical Oncology,Beijing Children's Hospital,Capital Medical University,were enrolled for hearing monitoring and statistical analysis using R language.Results 622 children were included in this study,of which 72(11.6%)developed hearing loss,and the median time of hearing loss was 12 months(1-124 months)after the initiation of platinum drugs.Multivariate analysis showed that cisplatin,cisplatin combined with carboplatin,cranial radiotherapy,and cisplatin with furosemide were associated with hearing loss(P<0.05).There was a nonlinear relationship between the cumulative cisplatin dose and hearing loss,with a 50%increase in the risk of hearing loss for every 100 mg/m2 increase in cisplatin when the cumulative cisplatin dose was greater than 680 mg/m2.The relationship between carboplatin and hearing loss was uncertain(P>0.05).Conclusion Cisplatin is associated with the risk of hearing loss in children with solid tumors.When the cumulative dose of cisplatin exceeds 680 mg/m2,the risk of hearing loss is significantly increased.关键词
儿童/实体肿瘤/抗肿瘤治疗/顺铂/卡铂/耳毒性Key words
Children/Solid tumors/Anti-tumor therapy/Cisplatin/Carboplatin/Ototoxicity分类
临床医学引用本文复制引用
童楚鸿,刘海红,白杰,刘晶,赵文,段超,王希思,金眉,马晓莉,苏雁..铂类药物所致实体肿瘤患儿听力损伤[J].中国听力语言康复科学杂志,2025,23(2):140-144,189,6.基金项目
国家自然科学基金"儿童神经母细胞瘤和肝母细胞瘤防控新策略研究"(82293660/82293665) （82293660/82293665）
国家重点研发计划资助"以数据驱动的儿童重大疾病临床用药规范和监管科学研究"(2023YFC2706100/2023YFC2706101) （2023YFC2706100/2023YFC2706101）
