中国现代医学杂志2025，Vol.35Issue(5)：60-65,6.DOI:10.3969/j.issn.1005-8982.2025.05.010
肝脏超声剪切波弹性成像在乙肝肝硬化患者肝纤维化程度评估中的应用价值
Application value of liver shear wave elastography in assessing hepatic fibrosis severity in patients with hepatitis B-related cirrhosis
摘要
Abstract
Objective To evaluate the application value of liver shear wave elastography(SWE)in assessing hepatic fibrosis severity in patients with hepatitis B-related cirrhosis(HBC).Methods A total of 98 HBC patients admitted to Xi'an Ninth Hospital Affiliated to Xi'an Jiaotong University from February 2023 to February 2024 were enrolled as the observation group(Child-Pugh class A:35 cases;B:33 cases;C:30 cases).Ninety-eight patients with chronic hepatitis B(CHB)during the same period were selected as the control group.Elastic modulus values,hepatic fibrosis severity,and serological markers[hyaluronic acid(HA),type Ⅳ collagen(Ⅳ-C),and laminin(LN)]were compared between groups.Receiver operating characteristic(ROC)curves were plotted to analyze the diagnostic efficacy of elastic modulus values and serological markers for HBC.Results The observation group exhibited significantly higher elastic modulus values,hepatic fibrosis severity,HA,Ⅳ-C,and LN levels compared to the control group(all P＜0.05).ROC analysis revealed the following diagnostic performance for HBC:elastic modulus[sensitivity:81.6％(95％CI:0.764,0.853),specificity:91.8％(95％CI:0.876,0.981),AUC:0.886(95％CI:0.832,0.940)];HA[sensitivity:82.7％(95％CI:0.792,0.886),specificity:79.6％(95％CI:0.732,0.843),AUC:0.844(95％CI:0.785,0.902)];Ⅳ-C[sensitivity:75.5％(95％CI:0.671,0.805),specificity:75.5％(95％CI:0.705,0.817),AUC:0.815(95％CI:0.755,0.876));LN[sensitivity:79.6％(95％CI:0.685,0.824),specificity:78.6％(95％CI:0.722,0.836),AUC:0.791(95％CI:0.724,0.858)].Patients with Child-Pugh class A had lower elastic modulus values,HA,Ⅳ-C,and LN levels than those with classes B and C(P＜0.05);class B patients had lower values than class C(P＜0.05).Conclusion Elastic modulus values strongly correlate with hepatic fibrosis severity in HBC patients,demonstrating that SWE provides an objective and quantitative assessment of liver fibrosis in this population.关键词
乙肝肝硬化/超声剪切波弹性成像/肝纤维化程度/肝功能分级/弹性模量值Key words
hepatitis B-related cirrhosis/shear wave elastography/hepatic fibrosis severity/Child-Pugh classification/elastic modulus分类
临床医学引用本文复制引用
乔旭东,朱照,骆瑞闯,王玲..肝脏超声剪切波弹性成像在乙肝肝硬化患者肝纤维化程度评估中的应用价值[J].中国现代医学杂志,2025,35(5):60-65,6.基金项目
陕西省重点研发计划项目(No:2022SF-278) （No:2022SF-278）
