中国现代医学杂志2025，Vol.35Issue(5)：66-71,6.DOI:10.3969/j.issn.1005-8982.2025.05.011
血清Del-1联合NISS评分对创伤患者近期预后的预测价值分析
Predictive value of serum Del-1 combined with NISS score for short-term prognosis in trauma patients
摘要
Abstract
Objective To explore the predictive value of serum developmental endothelial locus-1(Del-1)combined with the New Injury Severity Score(NISS)for short-term prognosis in trauma patients.Methods A total of 204 trauma patients admitted to Qingdao Municipal Hospital from June 2021 to May 2024 were enrolled.Based on 28-day follow-up outcomes,patients were divided into a survival group(n=1 83)and a death group(n=21).Clinical data,serum Del-1 levels,and NISS scores were compared between the two groups.Receiver operating characteristic(ROC)curves were constructed to evaluate the predictive value of serum Del-1 and NISS scores for short-term prognosis.Multivariate stepwise logistic regression was used to identify independent risk factors for prognosis.Results The death group had a higher proportion of patients aged ≥ 60 years,longer injury-to-admission time,higher rates of ventilator assistance,and greater trauma severity compared to the survival group.Systolic blood pressure(SBP),diastolic blood pressure(DBP),mean arterial pressure(MAP),Glasgow Coma Scale(GCS)scores,neutrophil elastase(NE)levels,and D-dimer levels were significantly higher in the death group(all P＜0.05).Serum Del-1 levels were lower(P＜0.05)and NISS scores were higher(P＜0.05)in the death group.The areas under the ROC curve(AUCs)for Del-1,NISS,and their combination were 0.859,0.746,and 0.906,respectively,with specificities of 63.71％,58.15％,and 85.02％,and sensitivities of 93.41％,93.41％,and 87.11％.Multivariate analysis identified independent risk factors for mortality:prolonged injury-to-admission time[OR=1.958(95％CI:1.414,2.711)],ventilator assistance[(OR)=2.106(95％CI:1.474,3.009)],higher GCS score[R(OR)=2.502(95％CI:1.651,3.791)],severe trauma[OR=2.385(95％CI:1.589,3.578)],reduced Del-1[OR=0.299(95％CI:0.184,0.484)],and elevated NISS score[(OR)=2.866(95％CI:1.848,4.446)](all P＜0.05).Conclusion Serum Del-1 and NISS scores are effective predictors of short-term prognosis in trauma patients,with enhanced predictive power when combined.关键词
创伤/内皮发育调节基因-1/新损伤严重程度评分/预后Key words
trauma/endothelial development regulatory gene-1/new injury severity score/prognosis分类
临床医学引用本文复制引用
刘鹏,刘萍,邵红,史光军,王丰艳..血清Del-1联合NISS评分对创伤患者近期预后的预测价值分析[J].中国现代医学杂志,2025,35(5):66-71,6.基金项目
山东省自然科学基金(No:ZR202103030420) （No:ZR202103030420）
