中国现代医学杂志2025，Vol.35Issue(5)：72-77,6.DOI:10.3969/j.issn.1005-8982.2025.05.012
终末期肾病透析患者血清去甲肾上腺素及血管紧张素Ⅱ在动静脉内瘘狭窄形成中的价值分析
Role of serum norepinephrine and angiotensin Ⅱ in arteriovenous fistula stenosis in dialysis patients with end-stage renal disease
摘要
Abstract
Objective To investigate the relationship between serum norepinephrine(NE)and angiotensin Ⅱ(Ang Ⅱ)levels and arteriovenous fistula(AVF)stenosis in dialysis patients with end-stage renal disease(ESRD)and evaluate their potential as biomarkers for AVF stenosis.Methods A total of 190 ESRD dialysis patients admitted to the Department of Nephrology at Xi'an Gaoxin Hospital from January 2021 to January 2024 were enrolled.Based on the presence of AVF stenosis,patients were divided into a stenosis group(n=64)and a non-stenosis group(n=126).Forty healthy adults from the same period served as the control group.Serum NE and Ang Ⅱ levels were compared among the three groups.Clinical data of ESRD dialysis patients were analyzed,and multivariate logistic regression was used to identify risk factors for AVF stenosis.Receiver operating characteristic(ROC)curves assessed the predictive value of NE and Ang Ⅱ for AVF stenosis.Results Compared to the control group,the stenosis and non-stenosis groups exhibited significantly higher serum NE and Ang Ⅱ levels(both P＜0.05).The stenosis group had lower albumin(Alb)levels and higher C-reactive protein(CRP),NE,and Ang Ⅱ levels than the non-stenosis group(all P＜0.05).Multivariate analysis identified elevated CRP[OR=1.331(95％CI:1.030,1.721)],NE[OR=1.015(95％CI:1.010,1.021)],and Ang Ⅱ[OR=1.101(95％CI:1.054,1.150)]as independent risk factors for AVF stenosis(all P＜0.05).Higher Alb levels were a protective factor[OR=0.248(95％CI:0.066,0.932)],P＜0.05].ROC analysis showed that combined NE and Ang Ⅱ testing had high predictive value for AVF stenosis[AUC=0.943(95％CI:0.904,0.982)],with a sensitivity of 84.4％(95％CI:0.731,0.922)and specificity of 93.7％(95％CI:0.879,0.972).Conclusion Elevated serum NE and Ang Ⅱ levels in ESRD dialysis patients are associated with AVF stenosis and may serve as predictive biomarkers.关键词
动静脉内瘘狭窄/终末期肾病/去甲肾上腺素/血管紧张素Ⅱ/透析Key words
arteriovenous fistula stenosis/end-stage renal disease/norepinephrine/angiotensin Ⅱ/dialysis分类
医药卫生引用本文复制引用
蔡东,姚向飞,权皎洁,石霄琼,王小玲..终末期肾病透析患者血清去甲肾上腺素及血管紧张素Ⅱ在动静脉内瘘狭窄形成中的价值分析[J].中国现代医学杂志,2025,35(5):72-77,6.基金项目
陕西省重点研发计划项目(No:2022SF-130) （No:2022SF-130）
