中国现代医学杂志2025，Vol.35Issue(5)：78-83,6.DOI:10.3969/j.issn.1005-8982.2025.05.013
血清HIF-1α、NSE、Hcy水平与急性缺血性脑卒中介入手术患者神经功能的关系
Association of serum HIF-1α,NSE,and Hcy levels with neurological function in acute ischemic stroke patients undergoing endovascular surgery
摘要
Abstract
Objective To analyze the correlation between serum hypoxia-inducible factor-lα(HIF-lα),neuron-specific enolase(NSE),homocysteine(Hcy)levels and neurological function in acute ischemic stroke(AIS)patients undergoing endovascular surgery.Methods Clinical data of 96 AIS patients who underwent endovascular surgery at Liaocheng Second People's Hospital from January 2022 to May 2024 were retrospectively analyzed.Patients were divided into a good recovery group(National Institutes of Health Stroke Scale[NIHSS]score＜15)and a poor recovery group(NIHSS score ≥15)based on 6-month postoperative outcomes.Baseline characteristics and serum HIF-1α,NSE,and Hcy levels were compared between groups.Multivariate logistic regression identified predictors of neurological outcomes,and receiver operating characteristic(ROC)curves assessed the predictive value of these biomarkers.Results Among 96 patients,27 had NIHSS scores ≥ 15.The poor recovery group exhibited higher rates of dyslipidemia(P＜0.05),carotid stenosis(P＜0.05),and elevated serum NSE(P＜0.05)and Hcy levels(P＜0.05),but lower HIF-1α levels(P＜0.05).Multivariate analysis identified independent risk factors for poor neurological recovery:dyslipidemia[OR=2.950(95％CI:1.039,8.378)],carotid stenosis[OR=2.560(95％CI:1.029,6.367)],low HIF-1α[OR=0.144(95％CI:0.049,0.420)],high NSE[OR=1.215(95％CI:1.074,1.374)],and high Hcy[(OR)=1.466(95％CI:1.220,1.760)](all P＜0.05).ROC analysis demonstrated that combined HIF-1α,NSE,and Hcy achieved an AUC of 0.954(95％CI:0.901,1.000)for predicting poor recovery,with 92.60％sensitivity(95％CI:0.905,1.000).The combined model showed significantly higher AUC and sensitivity than individual biomarkers(P＜0.05),but comparable specificity(P＞0.05).Conclusion Lower serum HIF-1α and elevated NSE/Hcy levels correlate with poorer neurological recovery in AIS patients post-endovascular surgery.The combined biomarkers exhibit strong predictive utility.关键词
急性缺血性脑卒中/缺氧诱导因子-1α/神经元特异性烯醇化酶/同型半胱氨酸/介入手术/神经功能Key words
acute ischemic stroke/hypoxia-inducible factor-1α/neuron-specific enolase/homocysteine/endovascular surgery/neurological function分类
临床医学引用本文复制引用
王高临,李斌,韩桂浩,马继光..血清HIF-1α、NSE、Hcy水平与急性缺血性脑卒中介入手术患者神经功能的关系[J].中国现代医学杂志,2025,35(5):78-83,6.基金项目
山东省医药卫生科技发展计划项目(No:2021BJ000028) （No:2021BJ000028）
