中国现代医学杂志2025，Vol.35Issue(5)：84-89,6.DOI:10.3969/j.issn.1005-8982.2025.05.014
布托啡诺与盐酸纳布啡对腰硬联合麻醉剖宫产产妇血流动力学及寒战发生的影响
Effects of butorphanol versus nalbuphine hydrochloride on hemodynamics and shivering in parturients undergoing cesarean section with combined spinal-epidural anesthesia
摘要
Abstract
Objective To compare the effects of intraoperative butorphanol and nalbuphine hydrochloride on hemodynamics and shivering in parturients receiving combined spinal-epidural anesthesia(CSEA)during cesarean section after fetal delivery.Methods Eighty-two parturients scheduled for cesarean section at Fuyang People's Hospital from April 2024 to October 2024 were enrolled and randomly divided into a butorphanol group(n=41)and a nalbuphine group(n=41).Mean arterial pressure(MAP),heart rate(HR),and oxygen saturation(SpO2)were measured at four time points:pre-medication after fetal delivery(T1),5 minutes post-medication(T2),uterine suture completion(T3),and surgery conclusion(T4).Ramsey Sedation Scores were assessed,and peri-anesthetic shivering incidence and adverse reactions were recorded.Results Hemodynamic parameters(MAP,HR,SpO2):(1)Significant temporal variations were observed in both groups(P＜0.05);(2)Intergroup comparisons showed lower MAP,HR and higher SpO2 in the butorphanol group versus the nalbuphine group(P＜0.05);(3)No significant differences in parameter trends between groups(P＞0.05).Ramsey Sedation Scores:(1)Scores varied significantly across time points(P＜0.05);(2)Butorphanol group exhibited higher scores than the nalbuphine group(P＜0.05);(3)No intergroup difference in score trends(P＞0.05).The nalbuphine group demonstrated higher peri-anesthetic shivering incidence(P＜0.05),with no intergroup difference in adverse reactions(P＞0.05).Conclusion Compared to nalbuphine,butorphanol administration during CSEA for cesarean section provides superior hemodynamic stability,reduced shivering incidence,and enhanced sedation efficacy without compromising safety.关键词
腰硬联合麻醉/布托啡诺/盐酸纳布啡/剖宫产/血流动力学/寒战/不良反应Key words
combined spinal-epidural anesthesia/butorphanol/nalbuphine hydrochloride/cesarean section/hemodynamics/shivering/adverse reactions分类
医药卫生引用本文复制引用
潘鑫,梁东锋,官双双,杨芳芳,蔡宁..布托啡诺与盐酸纳布啡对腰硬联合麻醉剖宫产产妇血流动力学及寒战发生的影响[J].中国现代医学杂志,2025,35(5):84-89,6.基金项目
安徽省自然科学基金(No:2308085MH250) （No:2308085MH250）
