中国现代医学杂志2025，Vol.35Issue(6)：1-5,5.DOI:10.3969/j.issn.1005-8982.2025.06.001
固定义齿修复牙列缺损的效果及对咀嚼功能和龈沟液TNF-α、IL-1β水平的影响
Efficacy of fixed dental prosthesis in repairing dentition defects and its impact on masticatory function and gingival crevicular fluid levels of TNF-α and IL-1β
摘要
Abstract
Objective To explore the efficacy of fixed dental prostheses in repairing dentition defects and its impact on masticatory function and the levels of TNF-α and IL-1β in gingival crevicular fluid.Methods The study included 86 patients with dentition defects treated at Yulin First Hospital from March 2021 to March 2023.Using a coin-flipping method,participants were divided into a control group(43 patients)treated with removable dentures and an observation group(43 patients)treated with fixed dental prostheses.The two groups were compared before and three months after treatment in terms of periodontal indices[Gingival Index(GI),Plaque Index(PI),Sulcus Bleeding Index(SBI)],occlusal function,masticatory function,oral health status[Oral Health Impact Profile-14(OHIP-14)],and inflammatory markers in gingival crevicular fluid[tumor necrosis factor-α(TNF-α),interleukin-1 β(IL-1β),serum amyloid A(SAA)].Results The observation group showed greater improvements in GI,PI,and SBI after treatment compared with the control group(P＜0.05).The excellent occlusal function rate was 93.02％in the observation group compared with 74.42％in the control group,indicating a better outcome in the observation group(P＜0.05).The differences of masticatory efficiency and OHIP-14 scores before and after treatment were greater in the observation group than in the control group(P＜0.05).The differences of levels of TNF-α,IL-1β,and SAA before and after treatment were also greater in the observation group compared with the control group(P＜0.05).Conclusions Fixed dental prosthesis effectively improves the periodontal health status,and occlusal and masticatory functions of patients with dentition defects,and reduces the levels of TNF-α,IL-1β,and SAA in the gingival crevicular fluid,thereby enhancing oral health and overall quality of life.关键词
固定义齿/牙列缺损/牙周指数/咀嚼功能/龈沟液炎症指标Key words
fixed dental prosthesis/dentition defects/periodontal indices/masticatory function/inflammatory markers in gingival crevicular fluid分类
口腔医学引用本文复制引用
雷彦华,郑海霞,郝亚男..固定义齿修复牙列缺损的效果及对咀嚼功能和龈沟液TNF-α、IL-1β水平的影响[J].中国现代医学杂志,2025,35(6):1-5,5.基金项目
陕西省重点研发计划一般项目(No:2022SF-096) （No:2022SF-096）
