中国现代医学杂志2025，Vol.35Issue(6)：12-16,5.DOI:10.3969/j.issn.1005-8982.2025.06.003
富血小板纤维蛋白填塞联合米诺环素治疗慢性根尖周炎对患者炎症反应的影响
Effect of platelet-rich fibrin packing combined with minocycline on inflammatory response in patients with chronic apical periodontitis
摘要
Abstract
Objective To investigate the effect of platelet-rich fibrin(PRF)packing combined with minocycline on inflammatory response in patients with chronic apical periodontitis(CAP).Methods We retrospective selected 103 CAP patients diagnosed and treated in our hospital between June 2020 to June 2023 and divided them into two groups according to the treatment method.The control group(52 cases)received minocycline ointment filling,while the observation group(51 cases)PRF packing combined with minocycline ointment filling.The curative effect,Visual Analogue Scale(VAS)scores,dental function,inflammation levels,quality of life and the safety profile were compared between the two groups.Results The success rate of the operation in the observation group was higher than that in the control group(P＜0.05).The differences in the VAS scores,neuropeptide Y,prostaglandin E2,masticatory efficiency,occlusal force,leukotriene B4,interleukin-1β,intercellular adhesion molecule-1,Toll-like receptor 4 and OHIP-5 scores before and after the operation in the observation group were greater compared with the control group(P＜0.05).There was no difference in the safety profile between the two groups(P＞0.05).Conclusions PRF packing combined with minocycline in the clinical treatment of CAP can effectively alleviate early postoperative pain and inflammation,improve surgical success rates,and enhance dental function and quality of life,while maintaining a high level of safety.关键词
慢性根尖周炎/富血小板纤维蛋白/米诺环素/生活质量/炎症反应/安全性Key words
chronic apical periodontitis/platelet-rich fibrin/minocycline/quality of life/inflammatory response/safety分类
口腔医学引用本文复制引用
任菁,王乐乐..富血小板纤维蛋白填塞联合米诺环素治疗慢性根尖周炎对患者炎症反应的影响[J].中国现代医学杂志,2025,35(6):12-16,5.基金项目
陕西省重点研发计划项目(No:2022SF-281) （No:2022SF-281）
