中国现代医学杂志2025，Vol.35Issue(6)：45-50,6.DOI:10.3969/j.issn.1005-8982.2025.06.008
外泌体调控自噬对肝脏相关疾病的作用及启示
The role of extracellular vesicle-mediated regulation of autophagy in liver diseases and its implications
摘要
Abstract
Extracellular vesicles(EVs)are essential mediators of intercellular communication,playing a key role in cell-to-cell information exchange,immune response,cell regeneration signaling,and differentiation.They are also widely involved in various pathophysiological processes,including cell autophagy,apoptosis,inflammation,and immune regulation.EVs affect the autophagy levels of recipient cells through their delivered contents.Autophagy is a cellular self-degradation program that degrades damaged organelles,misfolded proteins,and other molecules during cell senescence and death to provide energy support.Current research indicates that dysregulation of autophagy is closely associated with the pathogenesis and progression of liver diseases.Therefore,regulating autophagy could be a novel therapeutic target for liver diseases.This review highlights the importance of EVs and autophagy and discusses the clinical research and insights on EVs-mediated autophagy in liver diseases.关键词
肝脏疾病/外泌体/自噬Key words
liver disease/extracellular vesicle/autophagy分类
临床医学引用本文复制引用
陈玉,陈月桥,黄钰雯,潘李轶,裴浩,张雪,叶绿萍,王娜..外泌体调控自噬对肝脏相关疾病的作用及启示[J].中国现代医学杂志,2025,35(6):45-50,6.基金项目
国家自然科学基金(No:82160888),广西自然科学基金(No:2022GXNSFAA035573、No:2023GXNSFAA026361) （No:82160888）
