中国现代医学杂志2025，Vol.35Issue(6)：51-59,9.DOI:10.3969/j.issn.1005-8982.2025.06.009
时辰疗法:癌症个性化治疗新方向
Chronotherapy:A new direction in personalized therapy for cancer
摘要
Abstract
The circadian clocks help maintain homeostasis by regulating various metabolic and biological processes within organisms and cells.Disturbances in the body's circadian rhythm have been associated with the development and progression of cancer.The expression patterns of clock genes in cancer tissues differ from those in normal tissues.Disruption of circadian rhythms accelerates cancer cell proliferation and promotes the occurrence and progression of cancer by affecting cell cycle,regulating apoptosis,and other events.Given the crucial role of circadian rhythms in cancer progression,chronotherapy,tailored to the physiological rhythms of cancer tissues,has been widely studied in recent years.This review explores the composition and function of molecular clocks in cancer tissues,summarizes the current state of cancer chronotherapy,and highlights biomarkers from cutting-edge research that may guide personalized chronotherapy,aiming to provide new insights for the development of highly effective and precise personalized cancer chronotherapy.关键词
癌症/生物钟/昼夜节律紊乱/时辰疗法/生物标志物Key words
cancer/circadian clock/circadian rhythm disorder/chronotherapy/biomarkers分类
临床医学引用本文复制引用
马玥麟,王祥柱,陈敏慜..时辰疗法:癌症个性化治疗新方向[J].中国现代医学杂志,2025,35(6):51-59,9.基金项目
湖南省卫生健康委一般指导课题(No:202208025262) （No:202208025262）
中南大学研究生科研创新项目(自主探索类)(No:1053320230727) （自主探索类）
