中国现代医学杂志2025，Vol.35Issue(6)：84-90,7.DOI:10.3969/j.issn.1005-8982.2025.06.014
膀胱癌组织Ki-67、p53和CK-20的表达及与肿瘤病理特征和患者预后的关系
Expressions of Ki-67,p53,and cytokeratin 20 in bladder cancer tissues:Correlation with tumor pathological characteristics and patient prognosis
摘要
Abstract
Objective To analyze the relationship between the expressions of Ki-67,p53,and cytokeratin 20(CK-20)in bladder cancer tissues and tumor characteristics as well as patient prognosis.Methods A retrospective analysis of clinical data from 103 bladder cancer patients admitted to our hospital from January 2018 to February 2021 was performed.The expressions of Ki-67,p53,and CK-20 were examined in tumor tissues and adjacent non-tumor tissues.The positive expression rates of Ki-67,p53,and CK-20 in tumor tissues versus adjacent tissues were compared,and the correlations between protein expressions in tumor tissues and clinicopathological features(pathological pattern,clinical stage,number of tumors,tumor diameter,lymph node metastasis,invasiveness)were analyzed.A three-year postoperative follow-up was conducted for all patients,who were classified into the good prognosis(n=71)and poor prognosis(n=32)groups based on whether they experienced tumor recurrence,metastasis,new lesions,or death.The expressions of Ki-67,p53,and CK-20 in these groups were compared,and multivariable Logistic regression analysis was used to determine the association between protein expressions and prognosis.Results The positive expression rates of Ki-67,p53,and CK-20 in tumor tissues were significantly higher than those in adjacent tissues(P＜0.05).In patients with T3 and T4 stage tumors,lymph node metastasis,and invasive tumors,the positive expression rates of Ki-67,p53,and CK-20 in tumor tissues were even higher(P＜0.05).In the poor prognosis group,the positive expression rates of Ki-67,p53,and CK-20 in tumor tissues were also higher than those in the good prognosis group(P＜0.05).Multivariable Logistic regression analysis showed that high expressions of Ki-67[(OR)=8.699(95％CI:2.253,33.591)],p53[(OR)=10.582(95％CI:2.175,51.492)],and CK-20[(OR)=5.486(95％CI:1.375,21.885)]were independent risk factors for poor prognosis in bladder cancer patients(P＜0.05).ROC curve analysis indicated that the sensitivity of combined detection of Ki-67,p53,and CK-20 was 75.0％(95％CI:0.566,0.885),with a specificity of 77.5％(95％CI:0.660,0.865),and an area under the curve of 0.805(95％CI:0.720,0.890).Conclusions The expressions of Ki-67,p53,and CK-20 in bladder cancer tissues are increased and closely related to the postoperative prognosis of the patients.关键词
膀胱癌/细胞角蛋白20/Ki-67/p53/病理特征Key words
bladder cancer/cytokeratin 20/Ki-67/p53/pathological characteristics分类
临床医学引用本文复制引用
王梅利,杨玉成,卞振华,何垚澍,陈敏婕..膀胱癌组织Ki-67、p53和CK-20的表达及与肿瘤病理特征和患者预后的关系[J].中国现代医学杂志,2025,35(6):84-90,7.基金项目
江苏省中医药科技发展计划项目(No:MS2023066) （No:MS2023066）
