中国药房2025，Vol.36Issue(5)：624-629,6.DOI:10.6039/j.issn.1001-0408.2025.05.21
四君子汤有效成分治疗胃癌的作用机制及临床应用研究进展
Research progress on the mechanism and clinical application of the effective ingredients from Sijunzi decoction in the treatment of gastric cancer
摘要
Abstract
Gastric cancer is a common malignant tumor of the digestive tract and can be classified as"fullness of the stomach","epigastric pain","noise"and other categories in the field of traditional Chinese medicine.Sijunzi decoction is composed of Panax ginseng,Poria cocos,Atractylodes macrocephala,and honey-fried Glycyrrhiza uralensis,and it has the effect of tonifying qi and strengthening the spleen.This article summarizes the active ingredients,mechanism of action,and clinical application research progress of Sijunzi decoction in treating gastric cancer.The results show that the main active ingredients of Sijunzi decoction include ginsenosides,atractylenolide,pachymic acid,glycyrrhizic acid,etc.;Sijunzi decoction and its effective ingredients can play an anti-gastric cancer role by inhibiting the proliferation of gastric cancer cell,inducing apoptosis of gastric cancer cell,enhancing gastric cancer cell chemotherapy sensitivity,and inhibiting invasion and metastasis of gastric cancer cell.In addition,Sijunzi decoction can enhance the efficacy of chemotherapy drugs,strengthen the immune function of the body and lower serum cancer marker levels during the clinical treatment of gastric cancer.关键词
四君子汤/有效成分/胃癌/作用机制/临床疗效Key words
Sijunzi decoction/effective ingredients/gastric cancer/mechanism of action/clinical efficacy分类
药学引用本文复制引用
张红伟,党文飞,索欣,张茹,张岩,靳子明,窦霞..四君子汤有效成分治疗胃癌的作用机制及临床应用研究进展[J].中国药房,2025,36(5):624-629,6.基金项目
国家自然科学基金项目(No.82360944) （No.82360944）
甘肃省自然科学基金项目(No.25JRRA239) （No.25JRRA239）
甘肃省中医药科研课题(No.GZKP-2022-23) （No.GZKP-2022-23）
兰州市科技计划项目(No.2022-5-109) （No.2022-5-109）
