中国医学科学院学报2025，Vol.47Issue(1)：86-94,9.DOI:10.3881/j.issn.1000-503X.16053
5-甲基胞嘧啶RNA甲基化在非肿瘤性肾脏疾病中的研究进展
Current Progress of 5-Methylcytosine RNA Methylation in Non-Neoplastic Kidney Diseases
摘要
Abstract
RNA methylation is a key process in the epigenetic regulation of post-transcriptional gene expression.5-Methylcytosine(m5 C)is a type of RNA methylation,commonly existing in eukaryotic mRNA and non-coding RNAs.It mainly regulates transfer RNA stability,ribosomal RNA assembly,and mRNA translation,stability,and translation.RNA methylation is dynamically reversible and regulated by methyltransferase,dem-ethylase,and methylation recognition protein.It has been confirmed that aberrant m5 C RNA methylation is involved in the pathogenesis of non-neoplastic kidney diseases.This article summarizes the current progress of m5 C RNA methylation associated with non-neoplastic acute and chronic kidney diseases,aiming to provide potential targets for the diagnosis and treatment of such diseases.关键词
表观遗传学/RNA甲基化修饰/RNA/5-甲基胞嘧啶/肾脏疾病Key words
epigenetics/RNA methylation/RNA/5-methylcytosine/kidney diseases分类
医药卫生引用本文复制引用
张晨,赵自霞,吴私,栾军军,周华..5-甲基胞嘧啶RNA甲基化在非肿瘤性肾脏疾病中的研究进展[J].中国医学科学院学报,2025,47(1):86-94,9.基金项目
国家自然科学基金(82170740) （82170740）
