中国医学科学院学报2025，Vol.47Issue(1)：102-109,8.DOI:10.3881/j.issn.1000-503X.15884
铜稳态与疾病研究进展
Research Progress in Copper Homeostasis and Diseases
摘要
Abstract
As an indispensable trace element in the human body,copper plays an important role in various physiological and biochemical reactions.The dyshomeostasis of copper leads to the disorder of copper metabolism and the occurrence of related diseases.Cuproptosis,a newly proposed regulatory cell death mode,is different from the known apoptosis,pyroptosis,necroptosis,and ferroptosis.Recent studies have found that the dysho-meostasis of copper has been observed in a variety of cancers.Therefore,targeting copper for disease treatment may become a new strategy and a new idea.This article systematically summarizes the fundamental properties of copper,copper dyshomeostasis-related diseases(Menkes syndrome,Wilson’s disease,and cancer)and their treatment,and reviews the research progress in cuproptosis.关键词
铜稳态/铜代谢/铜死亡/癌症Key words
copper homeostasis/copper metabolism/cuproptosis/cancer分类
医药卫生引用本文复制引用
邱暑婷,谭晓华,邵诗涵,李愉,张盈盈,曹月佳,狄春红..铜稳态与疾病研究进展[J].中国医学科学院学报,2025,47(1):102-109,8.基金项目
国家自然科学基金面上项目(81772168)、浙江省自然科学基金(LY23H190001)和杭州师范大学研究生科研创新推进项目(2022HSDYJSKY240) （81772168）
