中国医学科学院学报2025，Vol.47Issue(1)：124-130,7.DOI:10.3881/j.issn.1000-503X.16038
代谢相关疾病与草酸钙结石形成机制的研究进展
Research Progress in Metabolism-Related Diseases and Formation Mechanism of Calcium Oxalate Stones
摘要
Abstract
Kidney stones are a urinary system disease with a high incidence,among which calcium oxalate stones are the most common.Metabolic disorders such as hypertension,diabetes,obesity,hyperlipi-demia,and hyperuricemia can cause changes in oxalate,uric acid,and pH and calcium ion concentrations in the urine through multiple pathways including inducing oxidative stress and inflammatory responses by generating reactive oxygen species,ultimately affecting the formation of calcium oxalate stones.This article reviews the pos-sible pathways and mechanisms by which metabolic diseases influence the formation of calcium oxalate stones,providing new ideas for the clinical prevention and treatment of calcium oxalate stones.关键词
草酸钙结石/代谢相关疾病/机制/活性氧Key words
calcium oxalate stone/metabolism-related diseases/mechanism/reactive oxygen species分类
医药卫生引用本文复制引用
岑威虎,沈俊,夏莎莎,王强..代谢相关疾病与草酸钙结石形成机制的研究进展[J].中国医学科学院学报,2025,47(1):124-130,7.基金项目
贵州省卫生健康委科学技术基金(gzwkj2021-220)、国家自然科学基金培育项目(gyfynsfc〔2020〕-30)和贵州医科大学附属医院博士科研启动基金(gyfybsky-2-31) （gzwkj2021-220）
