中国医学科学院学报2025，Vol.47Issue(1)：131-136,6.DOI:10.3881/j.issn.1000-503X.16055
免疫检查点抑制剂在复发及难治性性腺恶性生殖细胞肿瘤中的研究进展
Research Progress in Immune Checkpoint Inhibitors for Relapsed and Refractory Malignant Gonadal Germ Cell Tumors
摘要
Abstract
Germ cell tumors typically occur in the gonadal regions,characterized by high malignancy and rapid progression.Due to their high sensitivity to chemotherapy,the cure rate is generally high.However,a portion of patients still succumb to chemotherapy resistance and disease progression.The use of immune check-point inhibitors has significantly improved the prognosis for various solid tumors,while the immune mechanisms and efficacy of immunotherapy in germ cell tumors remain understudied.Whether relapsed and refractory germ cell tumors can benefit from immune checkpoint inhibitors remains to be investigated.In this review,we summarize the immune-related mechanisms,case reports,and clinical trials of immunotherapy in germ cell tumors to assess the effectiveness of this therapy,providing a reference for future basic research and clinical practice.关键词
恶性生殖细胞肿瘤/肿瘤微环境/免疫检查点抑制剂/临床试验Key words
malignant germ cell tumor/tumor microenvironment/immune checkpoint inhibitor/clinical trial分类
医药卫生引用本文复制引用
张天宇,杨佳欣..免疫检查点抑制剂在复发及难治性性腺恶性生殖细胞肿瘤中的研究进展[J].中国医学科学院学报,2025,47(1):131-136,6.基金项目
中国医学科学院医学与健康科技创新工程(2022-I2M-C&T-B-023) （2022-I2M-C&T-B-023）
