中国医院用药评价与分析2025，Vol.25Issue(2)：148-152,5.DOI:10.14009/j.issn.1672-2124.2025.02.005
基于数据挖掘的某院中药治疗慢性肾脏病的用药规律和用药安全性分析
Medication Rules and Safety of Traditional Chinese Medicine in the Treatment of Chronic Kidney Disease in A Hospital Based on Data Mining
摘要
Abstract
OBJECTIVE:To probe into the medication rules and safety of traditional Chinese medicine in the treatment of chronic kidney disease(CKD)based on data mining in a hospital.METHODS:The database of traditional Chinese medicine decoction pieces for patients with CKD in the hospital was established,and statistical analysis,association analysis,community analysis and cluster analysis were carried out by the cloud platform of ancient and modern medical records.RESULTS:A total of 52 133 traditional Chinese medicine prescriptions were collected from the Nephrology department of the hospital,including 4 225 prescriptions for patients with CKD,and the traditional Chinese medicine prescription database for patients with CKD was established.Among the 4 225 prescriptions,380 kinds of traditional Chinese medicine were included,and the cumulative frequency was 74 740 times.Totally 23 kinds of traditional Chinese medicine such as Hedysarum multijugum maxim,Radix Salviae,and Radix Rhei Et Rhizome were frequently used,involving 7 toxic traditional Chinese medicine drugs including Arum ternatum thunb,Aconiti lateralis radix praeparata and scorpioand.The core drug composition was"Radix Salviae-Hedysarum multijugum maxim-Radix Rhei Et Rhizome".By cluster analysis,the top 10 high-frequency drugs could be divided into three groups,"Hedysarum multijugum maxim,Radix Salviae","Poria Cocos,Radix Rhei Et Rhizome"and"Radix paeoniae rubra,Schizonepetae herba,Radix bupleuri,Hordei fructus germinatus,Sophora japonica and Rehmanniae radix praeparata".Both high-frequency drugs and toxic traditional Chinese medicine drugs had off-label drug use of the Pharmacopoeia of the People's Republic of China(Part 1,2020 edition).CONCLUSIONS:It is necessary to strengthen the monitoring of the use of traditional Chinese medicine decoction pieces and the monitoring of adverse reactions in patients with CKD,and pay attention to the safety of the use of traditional Chinese medicine decoction pieces with toxic and toxic components,so as to provide references for the clinical pharmaceutical care of patients with CKD.关键词
慢性肾脏病/用药规律/用药安全/临床中药学Key words
Chronic kidney disease/Medication rules/Medication safety/Clinical traditional Chinese medicine分类
药学引用本文复制引用
张婧,王景红,张冰,林志健,吴佳妮,张瑞丽,张梅竹..基于数据挖掘的某院中药治疗慢性肾脏病的用药规律和用药安全性分析[J].中国医院用药评价与分析,2025,25(2):148-152,5.基金项目
全国中药特色技术传承人才培训项目(No.国中医药人教函〔2023〕96 号) （No.国中医药人教函〔2023〕96 号）
北京市药学会课题(No.zy2020-18) （No.zy2020-18）
