中国医院用药评价与分析2025，Vol.25Issue(2)：157-160,4.DOI:10.14009/j.issn.1672-2124.2025.02.007
伏诺拉生联合阿莫西林、克拉霉素的三联方案根除幽门螺杆菌的效果评价研究
Efficacy Evaluation on Vorosuvastatin Combined with Amoxicillin and Clarithromycin in the Eradication of Helicobacter Pylori
摘要
Abstract
OBJECTIVE:To evaluate the efficacy and safety of vorosuvastatin combined with amoxicillin and clarithromycin in the eradication of Helicobacter pylori(Hp),so as to provide evidence for clinical decision-making.METHODS:A total of 180 patients diagnosed as requiring Hp eradication for the first time in the Dastroenterology department of the hospital from Jan.2022 to Jun.2023 were divided into the observation group 1,observation group 2 and control group by the random number table method,with 60 cases in each group.The observation group 1 and observation group 2 received a 7-day triple regimen of vorosuvastatin,amoxicillin and clarithromycin,with the only difference being the dosage of amoxicillin taken.The control group received a 7-day eradication regimen of esomeprazole,amoxicillin and clarithromycin.14 C urea breath test was reexamined 1 month after the end of anti-HP treatment.The eradication rate of Hp,improvement of clinical symptoms and occurrence of adverse drug reactions in three groups were analyzed.RESULTS:Among 180 patients,6 cases were lost to follow-up,including 1 case in observation group 1,2 cases in observation group 2,and 3 cases in the control group.The eradication rates of Hp in observation group 1,observation group 2,and control group was respectively 91.53％(54/59),91.38％(53/58),and 87.72％(50/57),there was a statistically significant difference(P<0.05)between observation group 1,observation group 2,and the control group.The three treatment regimens could effectively improve the symptoms of abdominal distension,acid reflux,oral odor,stomach pain,and bloating in patients,there was a statistically significant difference(P<0.05)between observation group 1,observation group 2,and the control group.The incidence of adverse drug reactions in observation group 1,observation group 2 and control group was respectively 6.78％(4/59),8.62％(5/58)and 10.53％(6/57),there was a statistically significant difference(P<0.05)between observation group 1,observation group 2,and the control group.CONCLUSIONS:The eradication of Hp and symptom improvement in the triple regimen of vorosuvastatin combined with amoxicillin and clarithromycin are superior to those based on the triple regimen of Esomeprazole magnesium enteric coated tablets,the treatment safety of the three regimens are comparable.关键词
伏诺拉生/三联方案/幽门螺杆菌/根除率Key words
Vonoprazan/Triple regimen/Helicobacter pylori/Eradication rates分类
药学引用本文复制引用
刘宏明,王敏,孟雅洁,王建..伏诺拉生联合阿莫西林、克拉霉素的三联方案根除幽门螺杆菌的效果评价研究[J].中国医院用药评价与分析,2025,25(2):157-160,4.基金项目
重庆市科卫联合医学科研项目(No.2022QNXM038) （No.2022QNXM038）
