中国医院用药评价与分析2025，Vol.25Issue(2)：172-175,4.DOI:10.14009/j.issn.1672-2124.2025.02.010
百令胶囊联合沙丁胺醇治疗慢性阻塞性肺疾病的疗效及对血清sTREM-1、MMP-9水平的影响
Efficacy of Bailing Capsules Combined with Salbutamol in the Treatment of Chronic Obstructive Pulmonary Disease and Its Effects on Serum sTREM-1 and MMP-9 levels
摘要
Abstract
OBJECTIVE:To probe into the efficacy of Bailing capsules combined with salbutamol in the treatment of chronic obstructive pulmonary disease(COPD)and its effects on serum soluble triggering receptor expressed on myeloid cell-1(sTREM-1)and matrix metalloproteinase-9(MMP-9)levels.METHODS:A total of 202 patients with acute exacerbation of COPD admitted into the hospital from Jun.2021 to May 2023 were selected to be divided into salbutamol group(101 cases)and Bailing group(101 cases)via random number table method.The salbutamol group was given salbutamol sulfate inhaled aerosol based on conventional treatment,while the Bailing group received Bailing capsules based on the salbutamol group,both groups were continuously treated for 8 weeks.The changes of serological indicators[sTREM-1,monocyte chemoattractant protein 1(MCP-1)and MMP-9],inflammatory indicators[procalcitonin(PCT)and C reactive protein(CRP)]and pulmonary function indicators[forced expiratory volume in 1 s(FEV1)and FEV1 as percentage of forced vital capacity(FEV1/FVC)]before and after treatment were measured and recorded,and the clinical efficacy of two groups were observed.RESULTS:After treatment,the PCT,CRP,sTREM-1,MCP-1 and MMP-9 levels of both groups were significantly lower than those before treatment,and those in the Bailing group were lower than the salbutamol group,with statistically significant differences(P<0.05).After treatment,the FEV1 and FEV1/FVC levels of both groups were significantly higher than those before treatment,and those in the Bailing group were higher than the salbutamol group,with statistically significant differences(P<0.05).After treatment,the clinical total effective rate of the salbutamol group was 77.23％(78/101),which was significantly lower than 93.07％(94/101)of the Bailing group,with statistically significant difference(P<0.05).CONCLUSIONS:Bailing capsules combined with salbutamol in the treatment of COPD can effectively inhibit the release of inflammatory mediators,reduce inflammatory reactions,improve pulmonary function and obviously enhance clinical efficacy.关键词
百令胶囊/沙丁胺醇/慢性阻塞性肺疾病/可溶性髓样细胞触发受体-1/基质金属蛋白酶-9Key words
Bailing capsules/Salbutamol/Chronic obstructive pulmonary disease/Soluble triggering receptor expressed on myeloid cell-1/Matrix metalloproteinase-9分类
药学引用本文复制引用
关博,陈立新,倪楠..百令胶囊联合沙丁胺醇治疗慢性阻塞性肺疾病的疗效及对血清sTREM-1、MMP-9水平的影响[J].中国医院用药评价与分析,2025,25(2):172-175,4.基金项目
辽宁省科学技术计划项目(No.2019-ZD-0427) （No.2019-ZD-0427）
