中国医院用药评价与分析2025，Vol.25Issue(2)：176-179,4.DOI:10.14009/j.issn.1672-2124.2025.02.011
恩格列净对2型糖尿病患者心外膜脂肪体积和心功能的影响
Effects of Empagliflozin on Epicardial Adipose Tissue Volume and Cardiac Function in Patients with Type 2 Diabetes Mellitus
摘要
Abstract
OBJECTIVE:To evaluate and compare the effects between empagliflozin and sitagliptin on epicardial adipose tissue volume and cardiac function in patients with type 2 diabetes mellitus(T2DM).METHODS:A total of 256 T2DM patients admitted into the hospital from Sept.2021 to Aug.2023 were enrolled to be divided into the empagliflozin group(128 cases)and sitagliptin group(128 cases)via random number table method.All patients were given Metformin hydrochloride tablets orally;the empagliflozin group was treated with Empagliflozin tablets orally every morning,10 mg each time for once a day;the sitagliptin group received Sitagliptin phosphate tablets orally,100 mg each time for once a day.All the patients were continuously treated for 24 weeks.The epicardial adipose tissue volume,myocardial triglyceride content,cardiac function indicators,metabolic indicators and incidences of adverse drug reaction were compared between empagliflozin group and sitagliptin group.RESULTS:After treatment,the epicardial adipose tissue volume(t=2.672,P=0.008)and myocardial triglyceride content(t=2.283,P=0.023)of the empagliflozin group were significantly lower than those of the sitagliptin group;the ratio of mitral blood flow velocity at early diastolic period to mitral annular blood flow velocity at early diastolic period(t=3.793,P<0.001)of the empagliflozin group was significantly lower than that of the sitagliptin group,the left ventricular ejection fraction(t=3.215,P=0.002),cardiac index(t=3.130,P=0.002)and the ratio of mitral blood flow velocity at early diastolic period to peak blood flow velocity at systolic period(t=2.114,P=0.036)of the empagliflozin group were significantly higher than those of the sitagliptin group;the fasting blood glucose(t=7.928,P<0.001)and insulin resistance index(t=10.777,P<0.001)of the empagliflozin group were significantly lower than those of the sitagliptin group,the blood ketone body(t=17.330,P<0.001)and β-hydroxybutyric acid(t=16.496,P<0.001)of the empagliflozin group were significantly higher than those of the sitagliptin group,the differences were statistically significant.After treatment,the difference in glycosylated hemoglobin levels between empagliflozin group and sitagliptin group were not statistically significant(t=0.718,P=0.473).And the difference in incidences of adverse drug reactions between empagliflozin group and sitagliptin group were not statistically significant[3.9％(5/128)vs.2.3％(3/128),χ2=0.129,P=0.719].CONCLUSIONS:Compared with sitagliptin,empagliflozin can significantly improve epicardial adipose tissue volume and cardiac function in T2DM patients,increase blood ketone body,improve insulin sensitivity and reduce the risk of cardiovascular disease complications.关键词
2型糖尿病/心外膜脂肪体积/心功能Key words
Type 2 diabetes mellitus/Epicardial adipose tissue volume/Cardiac function分类
药学引用本文复制引用
吕媛,孙悦,杜益飞..恩格列净对2型糖尿病患者心外膜脂肪体积和心功能的影响[J].中国医院用药评价与分析,2025,25(2):176-179,4.基金项目
2021 年陕西省卫健委卫生健康科研基金项目(No.2021yb356) （No.2021yb356）
