中国医院用药评价与分析2025，Vol.25Issue(2)：180-183,187,5.DOI:10.14009/j.issn.1672-2124.2025.02.012
复方苦参注射液联合mFOLFOX6化疗方案对湿热蕴结型结肠癌患者细胞免疫功能及肠道菌群的影响
Effects of Compound Kushen Injection Combined with mFOLFOX6 Chemotherapy on Cellular Immune Function and Intestinal Flora in Patients with Damp-Heat Accumulation Type Colon Cancer
摘要
Abstract
OBJECTIVE:To probe into the effects of compound Kushen injection combined with mFOLFOX6 chemotherapy(oxaliplatin+5-fluorouracil+calcium folinate)on the cellular immune function and intestinal flora in patients with damp-heat accumulation type colon cancer.METHODS:A total of 100 patients with stage Ⅲ to IV damp-heat accumulation type colon cancer admitted into the hospital from Mar.2022 to Jan.2024 were selected to be divided into observation group(given compound Kushen injection combined with mFOLFOX6 chemotherapy)and control group(given mFOLFOX6 chemotherapy alone)via complete randomization method,with 50 cases in each group.The effects of combined application of compound Kushen injection on clinical efficacy,traditional Chinese medicine syndrome cores,cellular immune function and intestinal flora in patients with damp-heat accumulation type colon cancer were observed.RESULTS:The objective remission rate of the observation group was 44.00％(22/50),significantly higher than 24.00％(12/50)of the control group,with statistically significant difference(P<0.05).After treatment,the improvement of traditional Chinese medicine syndrome scores in the observation group was better than that in the control group,with statistically significant difference(P<0.05).In terms of the cellular immune function,the CD4+and CD4+/CD8+levels of the observation group were significantly higher than those of the control group,while the CD8+level was lower than that of the control group,with statistically significant differences(P<0.05).Intestinal flora analysis indicated that the numbers of Bifidobacterium and Lactobacillus were significantly higher and the number of Escherichia coli was lower in the observation group than those in the control group,with statistically significant differences(P<0.05).The incidences of gastrointestinal reaction and myelosuppression of the observation group were lower than those of the control group,with statistically significant differences(P<0.05).CONCLUSIONS:Compound Kushen injection combined with mFOLFOX6 chemotherapy can significantly improve the clinical efficacy,cellular immune function and intestinal flora status in patients with damp-heat accumulation type colon cancer.关键词
结肠癌/复方苦参注射液/细胞免疫功能/肠道菌群Key words
Colon cancer/Compound Kushen injection/Cellular immune function/Intestinal flora分类
药学引用本文复制引用
胡嘉芮,何薇薇,王永霞,何晓华,籍强,渠少博,李占林..复方苦参注射液联合mFOLFOX6化疗方案对湿热蕴结型结肠癌患者细胞免疫功能及肠道菌群的影响[J].中国医院用药评价与分析,2025,25(2):180-183,187,5.基金项目
国家中西医协同"旗舰"科室建设项目(No.冀中医药〔2024〕11 号) （No.冀中医药〔2024〕11 号）
