中国医院用药评价与分析2025，Vol.25Issue(2)：184-187,4.DOI:10.14009/j.issn.1672-2124.2025.02.013
糖尿病泌尿系结石患者尿液病原菌及耐药性检测分析
Detection and Analysis of Urine Pathogenic Bacteria and Drug Resistance in Patients with Diabetic Urinary Calculus
摘要
Abstract
OBJECTIVE:To analyze the composition of urinary calculus and the distribution and drug sensitivity of pathogens in midstream urine of diabetic patients,so as to provide reference for rational application of antibiotics in clinical practice.METHODS:A total of 306 diabetic patients with urinary calculus admitted into the Urology Department of the hospital from May 2018 to Apr.2024 were selected.Infrared spectroscopy was used to detect the composition of the calculus,and conduct the pathogen culture as well as drug sensitivity testing on preoperative midstream urine.RESULTS:The 306 diabetic patients were mainly aged>50 years,with 177 cases(57.84％).The composition of urinary calculus of 306 diabetic patients were mainly magnesium ammonium phosphate hexahydrate,with 127 cases(41.50％).Of which calcium oxalate dihydrate was predominantly in male patients,with 38.42％(73/190).And magnesium ammonium phosphate hexahydrate was predominantly in female patients,with 65.52％(76/116).The compositions of calculus in patients with different ethnicities were mainly magnesium ammonium phosphate hexahydrate,the differences among ethnicities were not statistically significant(P>0.05).A total of 207 strains(67.65％)of pathogens were isolated from midstream urine bacterial culture,of which 96 strains were Escherichia coli and 63 strains were Streptococcus agalactiae.The drug sensitivity results showed that E.coli were 80.21％(77/96)resistant to ampicillin,Aspergillus singularis were 100％resistant to furotoxin,S.agalactiae were 82.54％(52/63)resistant to erythromycin,Staphylococcus epidermidis were 71.43％(5/7)resistant to penicillin and ampicillin,S.agalactiae and S.epidermidis were 100％sensitive to linezolid and vancomycin.CONCLUSIONS:Patients with diabetic urinary calculus are mainly infected calculus,the bacterial infections of midstream urine are mainly E.coli and S.agalactiae,and both with high drug resistance rate,the clinic should pay more attention.关键词
糖尿病/泌尿系结石/结石成分/细菌/无乳链球菌Key words
Diabetes/Urinary calculus/Calculus composition/Bacteria/Streptococcus agalactiae分类
药学引用本文复制引用
陈程,贾海英,贾宏亮,杨丽玮,郭淑丽..糖尿病泌尿系结石患者尿液病原菌及耐药性检测分析[J].中国医院用药评价与分析,2025,25(2):184-187,4.基金项目
新疆维吾尔自治区人民医院院内项目(No.20220117) （No.20220117）
