中国医院用药评价与分析2025，Vol.25Issue(2)：188-193,6.DOI:10.14009/j.issn.1672-2124.2025.02.014
益气通络类中药复方联合西药治疗糖尿病肾病的有效性与安全性的Meta分析
Meta-Analysis on Efficacy and Safety of Yiqi Tongluo Compound of Traditional Chinese Medicine Combined with Western Medicine in the Treatment of Diabetic Nephropathy
摘要
Abstract
OBJECTIVE:To discuss the efficacy and safety of Yiqi Tongluo compound of traditional Chinese medicine combined with Western medicine in the treatment of diabetic nephropathy based on Meta-analysis.METHODS:Chinese and English databases including CNKI,VIP,Wanfang Data,PubMed,Embase,and Web of Science were retrieved to collect randomized controlled trials of Yiqi Tongluo compound of traditional Chinese medicine combined with Western medicine in the treatment of diabetic nephropathy(the control group was treated with Western medicine,while the observation group received Yiqi Tongluo compound of traditional Chinese medicine on the basis of control group).The search time was from the establishment of the database to Jul.1st,2024.RevMan 5.3 software was used for data analysis and drawing.RESULTS:A total of 20 articles were included.Meta-analysis suggested that compared with the control group,the total effective rate in the observation group increased(OR=3.67,95％CI=2.71-4.99,P<0.000 01),fasting blood glucose(SMD=-0.69,95％CI=-0.81--0.56,P<0.000 01),2 h postprandial blood glucose(SMD=-1.20,95％CI=-1.41--1.00,P<0.000 01),glycosylated protein(SMD=-0.71,95％CI=-0.87--0.54,P<0.000 01),total cholesterol(SMD=-0.62,95％CI=-0.77--0.46,P<0.000 01),triacylglycerol(SMD=-0.88,95％CI=-1.04--0.71,P<0.000 01),low density lipoprotein cholesterol(SMD=-0.94,95％CI=-1.65--0.23,P=0.009)and renal function indicators(serum creatinine,urea nitrogen,24 h urinary protein quantity,urinary β2 microglobulin)levels decreased significantly(P<0.05),the differences were statistically significant.The incidence of adverse drug reactions in observation group was lower than that in control group,the difference was not statistically significant(OR=0.81,95％CI=0.42-1.57,P=0.53).CONCLUSIONS:Yiqi Tongluo compound of traditional Chinese medicine combined with Western medicine can improve the clinical total effective rate in patients with diabetic nephropathy,reduce adverse drug reactions,control blood sugar and blood lipid levels and significantly improve renal function,which is worthy of clinical application.关键词
益气通络/糖尿病肾病/Meta分析Key words
Yiqi Tongluo/Diabetic nephropathy/Meta-analysis分类
医药卫生引用本文复制引用
赵莉,马居里,刘金响,曹文斌,袁秀丽,秦刚新,苏衍进..益气通络类中药复方联合西药治疗糖尿病肾病的有效性与安全性的Meta分析[J].中国医院用药评价与分析,2025,25(2):188-193,6.基金项目
国家自然科学基金资助项目(No.82174335) （No.82174335）
陕西省科技厅课题(No.2020SF-336) （No.2020SF-336）
