中国医院用药评价与分析2025，Vol.25Issue(2)：194-199,206,7.DOI:10.14009/j.issn.1672-2124.2025.02.015
榄香烯注射液对非小细胞肺癌化疗后不良反应发生率影响的系统评价与Meta分析
Systematic Review and Meta-Analysis on Effects of Elemene Injection on Incidence of Adverse Drug Reactions After Chemotherapy in Non-Small Cell Lung Cancer
摘要
Abstract
OBJECTIVE:To evaluate the effects of elemene injection on incidence of adverse drug reactions after chemotherapy in non-small cell lung cancer.METHODS:CNKI,Wanfang Data,VIP,PubMed,Web of Science and the Cochrane Library were comprehensively retrieved by the combination of subject headings and keywords to collect the clinical randomized controlled trial(the control group was treated with conventional chemotherapy combined with drugs,while the study group received elemene injection on this basis)of elemene injection in the adjuvant treatment of chemotherapy patients with non-small cell lung cancer.The retrieval time was from the establishment of the database to Jun.30th,2024.Relevant literature were screened according to inclusion and exclusion criteria,data extraction and quality evaluation were carried out,and statistical analysis was performed by using RevMan 5.3 software.RESULTS:Totally 14 articles were included.Meta-analysis showed that the incidence of grade Ⅰ to Ⅱ hemoglobin reduction(RR=0.88,95％CI=0.70-1.11,P=0.28)and the incidence of grade Ⅰ to Ⅱ liver function impairment(RR=0.93,95％CI=0.72-1.19,P=0.56)between two groups were not statistically significant.The incidences of grade Ⅲto Ⅳ hemoglobin reduction(RR=0.42,95％CI=0.24-0.74,P=0.003),leukopenia(grade Ⅰ to Ⅱ:RR=0.71,95％CI=0.59-0.86,P=0.000 6;grade Ⅲ to Ⅳ:RR=0.42,95％CI=0.30-0.57,P<0.000 01),incidence of thrombocytopenia(grade Ⅰ to Ⅱ:RR=0.76,95％CI=0.61-0.94,P=0.01;grade Ⅲ to Ⅳ:RR=0.30,95％CI=0.19-0.48,P<0.000 01),incidence of grade Ⅲ to Ⅳ liver impairment(RR=0.44,95％CI=0.26-0.75,P=0.003),incidence of nausea and vomiting(grade Ⅰ to Ⅱ:RR=0.82,95％CI=0.74-0.92,P=0.000 7;grade Ⅲ toⅣ:RR=0.45,95％CI=0.28-0.73,P=0.001),and incidence og peripheral neuritis(RR=0.59,95％CI=0.36-0.97,P=0.04)were lower than those of the control group,with statistically significant differences.CONCLUSIONS:Elemene injection can effectively reduce the incidence of moderate to severe adverse drug reactions induced by chemotherapy in patients with non-small cell lung cancer,protect the liver,and alleviate the clinical symptoms of adverse drug reactions.关键词
化疗/非小细胞肺癌/榄香烯/不良反应发生率/Meta分析Key words
Chemotherapy/Non-small cell lung cancer/Elemene/Incidence of adverse drug reactions/Meta-analysis分类
医药卫生引用本文复制引用
宋睿,浩育盈,司海龙,马一鸣,赵粉莹..榄香烯注射液对非小细胞肺癌化疗后不良反应发生率影响的系统评价与Meta分析[J].中国医院用药评价与分析,2025,25(2):194-199,206,7.基金项目
国家自然科学基金资助项目(No.81704066) （No.81704066）
陕西省科技厅课题(No.2022SF-316) （No.2022SF-316）
2023 咸阳市科技局课题(No.L2023-ZDYF-SF-040) （No.L2023-ZDYF-SF-040）
2022 年中华中医药学会护理专业发展课题(No.HLKT-CACM-2022-1-10) （No.HLKT-CACM-2022-1-10）
陕西中医药大学校级课题(No.2023GP21) （No.2023GP21）
