中国医院用药评价与分析2025，Vol.25Issue(2)：207-210,214,5.DOI:10.14009/j.issn.1672-2124.2025.02.017
基于属性层次模型结合加权优劣解距离法的利妥昔单抗药物利用评价
Drug Utilization Evaluation of Rituximab Based on Attribute Hierarchy Model Combined with Weighted TOPSIS Method
摘要
Abstract
OBJECTIVE:To establish an evaluation system for rational clinical use of rituximab injection,so as to provide reference for rational clinical drug use.METHODS:According to the relevant drug instructions,clinical guidelines and expert consensus,the drug utilization evaluation(DUE)for rituximab injection were formulated.The attribute hierarchy model(AHM)combined with weighted technique for order preference by similarity to an ideal solution(TOPSIS)was used to evaluate the rationality of rituximab in 204 medical records in the hospital from Jan.2023 to Jun.2024.RESULTS:Among the 204 medical records,the relative proximity(Ci)was from 50.59％to 100.00％.There were 14 cases(6.86％)with 50％≤Ci<60％,45 cases(22.06％)with 60％≤Ci<70％,70 cases(34.31％)with 70％≤Ci<80％,and 49 cases(24.02％)with 80％≤Ci<90％;there were 26(12.75％)with Ci of 100.00％.The irrationality mainly focused on the course record,precautions,adverse drug reactions monitoring and treatment,pre-treatment,administration frequency and indications.CONCLUSIONS:The established DUE criteria of rituximab can be used to evaluate the rationality of clinical use of rituximab.There are many irregularities in the use of rituximab in the hospital,and it is necessary to strengthen clinical intervention.关键词
利妥昔单抗/药物利用评价/属性层次模型/加权优劣解距离法/合理用药Key words
Rituximab/Drug utilization evaluation/Attribute hierarchy model/Weighted TOPSIS method/Rational drug use分类
医药卫生引用本文复制引用
程赛赛,刘洪峰,孟现奇,周碧,朱峰..基于属性层次模型结合加权优劣解距离法的利妥昔单抗药物利用评价[J].中国医院用药评价与分析,2025,25(2):207-210,214,5.基金项目
2023 年安徽省临床医学研究转化专项(No.202304295107020119) （No.202304295107020119）
