中国合理用药探索2025，Vol.22Issue(2)：30-34,5.DOI:10.3969/j.issn.2096-3327.2025.02.005
萘莫司他——血液净化抗凝新选择
Nafamostat:A New Anticoagulation Choice for Blood Purification
摘要
Abstract
Nafamostat mesylate(NM)shows obvious advantages in prolonging filter lifespan and reducing bleeding risks due to its favorable biological properties,and it is also easier to operate than regional citrate anticoagulation.NM has been used for anticoagulation during extracorporeal circulation for more than 30 years and has shown excellent extracorporeal anticoagulation performance,especially in patients at high risk of bleeding.This article introduces the mechanism of action,application methods,and the use of NM in different bleeding risks and hypercoagulable states,and provides a comparison of the characteristics of four anticoagulation methods(NM,unfractionated heparin,low-molecular-weight heparin and regional citrate anticoagulation),contributing to the rational clinical use of anticoagulants.关键词
萘莫司他/抗凝/血液净化/枸橼酸/局部抗凝Key words
nafamostat/anticoagulation/blood purification/citrate/regional anticoagulation分类
药学引用本文复制引用
李双双,赵德鹏,丁征..萘莫司他——血液净化抗凝新选择[J].中国合理用药探索,2025,22(2):30-34,5.基金项目
2022年度北京市慢性病防治与健康教育科研项目(BJMB0012022028007) （BJMB0012022028007）
