摘要
Abstract
Objective:To investigate the clinical efficacy of Chaihu Longgu Muli decoction in treating patients with insomnia accompanied by depression and anxiety.Methods:A total of 75 patients with insomnia accompanied by depression and anxiety treated in our hospital and Henan Integrative Medicine Hospital from November 1,2023 to March 31,2024 were selected and assigned to the control group(2 dropouts,n=36)and observation group(2 dropouts,n=35)by random number table method.The control group was treated with dexzopiclone tablets combined with trazodone hydrochloride tablets,and the observation group was treated with Chaihu Longgu Muli decoction in addition to the treatment given in the control group.Both groups were treated for 4 weeks.The scores of Pittsburgh sleep quality index(PSQI)scale,insomnia severity index(ISI)scale,Hamilton depression scale(HAMD)and Hamilton anxiety scale(HAMA),clinical efficacy and adverse reactions were compared between the two groups.Results:After 2 and 4 weeks of treatment,the scores of PSQI and ISI were decreased in both groups(P<0.05).The scores of PSQI and ISI in the observation group were lower than those in the control group after 4 weeks of treatment(P<0.05).The scores of HAMD and HAMA were decreased in both groups after 4 weeks of treatment(P<0.05),and the scores of HAMD and HAMA in the observation group were lower than those in the control group after 2 and 4 weeks of treatment(P<0.05).The total effective rate in the observation group(91.43%)was higher than that in the control group(77.78%,P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(χ2=2.129,P=0.145>0.05).Conclusion:Chaihu Longgu Muli decoction combined with conventional western medicine shows better clinical efficacy in treating patients with insomnia accompanied by depression and anxiety,significantly improving the severity of insomnia,sleep quality and symptoms of depression and anxiety,without increasing the risk of adverse reactions.关键词
柴胡加龙骨牡蛎汤/失眠伴抑郁焦虑/临床疗效/睡眠障碍量表/焦虑抑郁量表Key words
Chaihu Longgu Muli decoction/insomnia accompanied by depression and anxiety/clinical efficacy/sleep disturbance scale/anxiety and depression scale分类
中医学
