中国合理用药探索2025，Vol.22Issue(2)：118-122,5.DOI:10.3969/j.issn.2096-3327.2025.02.020
和胃降逆方治疗慢性萎缩性胃炎伴肠上皮化生的临床研究
Clinical Study of Hewei Jiangni Recipe in Treating Chronic Atrophic Gastritis with Intestinal Metaplasia
摘要
Abstract
Objective:To investigate the clinical efficacy of Hewei Jiangni recipe in treating chronic atrophic gastritis(CAG)with intestinal metaplasia(IM).Methods:A total of 48 inpatients from the hepatobiliary,spleen and gastroenterology department of a hospital,admitted from October 1,2023 to September 30,2024 were selected and assigned to the control group and observation group by random number table method,with 24 patients in each group.Both groups underwent questionnaire surveys on personal history,family history,dietary and lifestyle habits,etc.,and were given basic treatments such as eradication of Helicobacter pylori and gastric mucosal protection.The control group was treated with Weifuchun capsule,and the observation group was treated with Hewei Jiangni recipe.Both groups were treated for 3 months.The traditional Chinese medicine(TCM)symptom(epigastric pain,abdominal distension,belching,acid regurgitation,poor appetite)scores,gastric mucosal tissue scores,pepsinogen Ⅰ(PG Ⅰ),pepsinogen Ⅱ(PG Ⅱ),pepsinogen ratio(PGR),clinical efficacy and adverse reactions were compared between the two groups.Results:After treatment,the TCM symptom scores were decreased in both groups(P<0.05),and the observation group showed lower scores compared to the control group(P<0.05).The gastric mucosal tissue scores were decreased in both groups(P<0.05),with the observation group showing lower scores than the control group(P<0.05).The level of PG Ⅰ was increased in both groups(P<0.05),with the observation group showing higher level than the control group(P<0.05).The level of PG Ⅱ was decreased in both groups(P<0.05),but there was no statistically significant difference between the two groups(P>0.05).The PGR in the observation group was higher than that before treatment(P<0.05),and higher than that in the control group(P<0.05).The total response rate in the observation group(91.67%)was higher than that in the control group(75.00%,P<0.05).No abnormal liver and kidney function was found in the two groups during treatment.Conclusion:Hewei Jiangni recipe can significantly alleviate the clinical symptoms of CAG patients with IM,improve gastroscopic,pathological scores and gastric mucosal function,with definite clinical efficacy.关键词
和胃降逆方/慢性萎缩性胃炎/肠上皮化生/临床研究/中医药治疗Key words
Hewei Jiangni recipe/chronic atrophic gastritis/intestinal metaplasia/clinical study/traditional Chinese medicine treatment分类
医药卫生引用本文复制引用
丁伟亮,王玉芹,谭波..和胃降逆方治疗慢性萎缩性胃炎伴肠上皮化生的临床研究[J].中国合理用药探索,2025,22(2):118-122,5.基金项目
潍坊市中医药科研立项项目(WFZYY2023-4-017) （WFZYY2023-4-017）
