中国中药杂志2025，Vol.50Issue(3)：575-582,8.DOI:10.19540/j.cnki.cjcmm.20240919.401
重视机体铁代谢对骨质疏松症的影响及中医药调控效用
Influence of iron metabolism on osteoporosis and modulating effect of traditional Chinese medicine
摘要
Abstract
Recent studies have shown that an imbalance in iron metabolism can affect the composition and microstructural changes of bone,disrupting bone homeostasis and leading to osteoporosis(OP).The imbalance in iron metabolism,along with its induced local abnormal microenvironment and cellular iron death,has become a new focal point in OP research,drawing increasing attention from the academic community regarding the regulation of iron metabolism to prevent and manage OP.From the perspective of traditional Chinese medicine(TCM),iron metabolism imbalance has potential connections to TCM theories regarding internal organs,as well as treatments aimed at tonifying the kidney,strengthening the spleen,and activating blood circulation.Evidence is continually emerging that TCMs and effective components that tonify the kidney,strengthen the spleen,and activate blood circulation can prevent and manage OP by regulating iron metabolism.This article analyzes the relationship between iron and bone,as well as the effects of TCM formulations on improving iron metabolism and influencing bone metabolism,from the perspectives of iron metabolism mechanisms and TCM interventions,aiming to broaden existing clinical strategies for prevention and treatment and inject new momentum into the field of OP as it moves into a new era.关键词
铁代谢/骨质疏松症/骨代谢/中医药/铁死亡Key words
iron metabolism/osteoporosis/bone metabolism/traditional Chinese medicine/ferroptosis引用本文复制引用
章轶立,齐保玉,孙传睿,郭翔云,杨双杰,刘平,魏戌..重视机体铁代谢对骨质疏松症的影响及中医药调控效用[J].中国中药杂志,2025,50(3):575-582,8.基金项目
国家自然科学基金项目(82205140) （82205140）
2022年青年岐黄学者培养项目(国中医药人教函[2022]256号) （国中医药人教函[2022]256号）
江苏省科技计划专项资金-基础研究计划自然科学基金项目(BK20220468) （BK20220468）
