中国中药杂志2025，Vol.50Issue(3)：609-619,11.DOI:10.19540/j.cnki.cjcmm.20241114.103
积雪草三萜类成分生物合成研究进展
Research progress on biosynthesis of triterpenoids in Centella asiatica
摘要
Abstract
The triterpenoid saponins of Centella asiatica,including asiaticoside,madecassoside,asiatic acid,and madecassic acid,are pivotal bioactive compounds of the plant.These constituents exhibit a spectrum of pharmacological activities,such as antioxidant,antitumor,and antidepressant effects,promotion of wound healing,and enhancement of microcirculation.Owing to these therapeutic properties,C.asiatica is widely employed in pharmaceutical and cosmetic industries.However,the escalating global demand for its extracts has led to potential supply shortages,prompting researchers to use multiple strategies such as multi-omics,molecular biology,and synthetic biology to conduct extensive studies.These studies encompass the elucidation of the biosynthetic pathways of triterpenoid saponins in C.asiatica,metabolic regulation,the hormonal induction of secondary metabolite synthesis,and the application of biotechnological strategies for natural product production to increase the yield of secondary metabolites in C.asiatica,or to produce active components via microbial chassis,thus satisfying market demands and promoting the sustainable exploitation of wild C.asiatica resources.This article first introduced the triterpenoid saponins of C.asiatica and their biological activities,then summarized the latest research advancements in their biosynthetic pathways,metabolic regulation,and heterologous biosynthesis,and provided an outlook on future development directions,with the aim of providing reference for comprehensive resource development and biotechnological synthesis of active components from C.asiatica.关键词
积雪草/三萜皂苷/生物合成途径/代谢调控/异源合成Key words
Centella asiatica/triterpenoid saponin/biosynthetic pathway/metabolic regulation/heterologous biosynthesis引用本文复制引用
周佩娜,陈斌,束成杰,李卓航,陈鹏,费程浩..积雪草三萜类成分生物合成研究进展[J].中国中药杂志,2025,50(3):609-619,11.基金项目
国家自然科学基金项目(82404814,82404863) （82404814,82404863）
南京农业大学科研启动经费项目(130-804141) （130-804141）
