中国中药杂志2025，Vol.50Issue(3)：632-643,12.DOI:10.19540/j.cnki.cjcmm.20241014.302
细胞程序性死亡在肺癌中的分子机制及中医药干预进展
Molecular mechanism of programmed cell death in lung cancer and progress in traditional Chinese medicine intervention
摘要
Abstract
Lung cancer is one of the most common and deadliest cancers globally,with its incidence and mortality rates rising each year.Therefore,finding new,safe,and effective alternative therapies poses a significant research challenge in this field.Programmed cell death refers to the process by which cells actively self-destruct in response to specific stimuli,regulated by genetic mechanisms.Modern research indicates that dysregulation of programmed cell death is widespread in the occurrence and progression of lung cancer,allowing cancer cells to evade death while continuing to proliferate and metastasize.Thus,inducing the death of lung cancer cells can be considered a novel therapeutic strategy for treating the disease.In recent years,research on traditional Chinese medicine(TCM)in the field of oncology has gained widespread attention,becoming a focal point.An increasing number of studies have demonstrated that TCM can inhibit the progression of lung cancer and exert anti-cancer effects by inducing apoptosis,necroptosis,pyroptosis,autophagy,and ferroptosis.This paper provided a comprehensive review of the molecular mechanisms of programmed cell death in lung cancer,along with the potential mechanisms and research advancements related to the regulation of these processes by TCM,so as to establish a theoretical foundation and direction for future basic and clinical research on lung cancer.关键词
细胞程序性死亡/肺癌/分子机制/中医药Key words
programmed cell death/lung cancer/molecular mechanism/traditional Chinese medicine引用本文复制引用
罗成,宁博,张馨月,霍誉之,吴新辉,叶远航,王飞..细胞程序性死亡在肺癌中的分子机制及中医药干预进展[J].中国中药杂志,2025,50(3):632-643,12.基金项目
国家重点研发计划项目(2020YFC2003104) （2020YFC2003104）
国家自然科学基金面上项目(82174347) （82174347）
四川省科技创新苗子工程培育项目(MZGC20230053) （MZGC20230053）
