中国中药杂志2025，Vol.50Issue(3)：644-657,14.DOI:10.19540/j.cnki.cjcmm.20240828.701
NLRP3炎症小体的天然小分子化合物抑制剂研究进展
Research progress on natural small molecule compound inhibitors of NLRP3 inflammasome
摘要
Abstract
In recent years,there has been a growing interest in the research on NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome inhibitors in the treatment of inflammatory diseases.The NLRP3 inflammasome is integral to the innate immune response,and its abnormal activation can lead to the release of pro-inflammatory cytokine,consequently facilitating the progression of various pathological conditions.Therefore,investigating the pharmacological inhibition pathway of the NLRP3 inflammasome represents a promising strategy for the treatment of inflammation-related diseases.Currently,the Food and Drug Administration(FDA)has not approved drugs targeting the NLRP3 inflammasome for clinical use due to concerns regarding liver toxicity and gastrointestinal side effects associated with chemical small molecule inhibitors in clinical trials.Natural small molecule compounds such as polyphenols,flavonoids,and alkaloids are ubiquitously found in animals,plants,and other natural substances exhibiting pharmacological activities.Their abundant sources,intricate and diverse structures,high biocompatibility,minimal adverse reactions,and superior biochemical potency in comparison to synthetic compounds have attracted the attention of extensive scholars.Currently,certain natural small molecule compounds have been demonstrated to impede the activation of the NLRP3 inflammasome via various action mechanisms,so they are viewed as the innovative,feasible,and minimally toxic therapeutic agents for inhibiting NLRP3 inflammasome activation in the treatment of both acute and chronic inflammatory diseases.Hence,this study systematically examined the effects and potential mechanisms of natural small molecule compounds derived from traditional Chinese medicine on the activation of NLRP3 inflammasomes at their initiation,assembly,and activation stages.The objection is to furnish theoretical support and practical guidance for the effective clinical application of these natural small molecule inhibitors.关键词
NLRP3炎症小体/中草药/天然小分子化合物/抑制剂/炎症性疾病Key words
NLRP3 inflammasome/Chinese herbal medicine/natural small molecule compounds/inhibitor/inflammatory disease引用本文复制引用
张田圆,陈希瑜,段欣钰,赵倩茹,马琳,晏一淇,王彧,刘陶,王少峡..NLRP3炎症小体的天然小分子化合物抑制剂研究进展[J].中国中药杂志,2025,50(3):644-657,14.基金项目
国家自然科学基金项目(82141201,82405164) （82141201,82405164）
中国博士后科学基金第74批面上项目(2023M742626) （2023M742626）
国家资助博士后研究人员计划(C档)项目(GZC20231927) （C档）
