中国中药杂志2025，Vol.50Issue(4)：853-859,7.DOI:10.19540/j.cnki.cjcmm.20241025.601
中药配伍减毒新策略新方法:成分靶标效应互作
New strategy and method in traditional Chinese medicine compatibility for detoxification based on component-target-effect interaction
摘要
Abstract
The safety of traditional Chinese medicine(TCM)has always been taken very seriously,and rich and valuable theories and experiences have been developed to ensure the safe and precise use of TCM in clinical practices.In recent years,the cognitive theory of toxicity of TCM,has undergone a profound change.TCM is characterized by the existence of intrinsic toxicity,idiosyncratic toxicity,and indirect toxicity related to organic factors.Therefore,the traditional theories and experiences of TCM,which focus on the prevention and control of intrinsic toxicity,fail to be used for the development of risk prevention and control countermeasures for newly discovered TCM with idiosyncratic toxicity and indirect toxicity.Accordingly,based on the toxicity classification and mechanism characteristics of TCM,this paper proposed a new strategy and method in TCM compatibility for detoxification based on component-target-effect interaction.The strategy based on component-target-effect interaction is to carry out TCM compatibility for detoxification by blocking the occurrence of drug-mediated damage and promoting damage repair through component interactions,target interactions,and/or effect interactions.Based on this theory,the paper established a strategy for TCM compatibility that aligned with the cognitive theory of toxicity of TCM,so as to achieve safe and precise use of TCM in clinical practices.The strategy based on component-target-effect interaction has been exemplarily applied to the development of countermeasures to reduce the toxicity of TCM,including Polygonum Multiflorum,Epimedii Folium,and Psoraleae Fructus,and a new mechanism of Glycyrrhizae Radix et Rhizoma to"harmonize various medicines and detoxify myriad poisons"was illustrated,providing a scientific basis for the safe and precise use of TCM in clinical practice.This paper explained the scientific connotation,application forms,and application examples of component-target-effect interaction,aiming to provide a theoretical and methodological basis for guaranteeing the precise use of TCM in clinical practice and innovate the theories and methods of TCM compatibility for detoxification.关键词
中药毒性/配伍减毒/成分靶标效应互作/安全精准用药Key words
toxicity of traditional Chinese medicine(TCM)/compatibility for detoxification/component-target-effect interaction/safe and precise use of TCM引用本文复制引用
柏兆方,石伟,高源,王伽伯,肖小河..中药配伍减毒新策略新方法:成分靶标效应互作[J].中国中药杂志,2025,50(4):853-859,7.基金项目
国家自然科学基金联合基金重点项目(U23A20519) （U23A20519）
国家自然科学基金项目(82230118) （82230118）
中央本级重大增减支项目(2060302) （2060302）
