中国中药杂志2025，Vol.50Issue(4)：860-873,14.DOI:10.19540/j.cnki.cjcmm.20240923.401
中药治疗溃疡性结肠炎的研究进展
Research progress in treatment of ulcerative colitis with traditional Chinese medicine
摘要
Abstract
Ulcerative colitis(UC)is a chronic,non-specific inflammatory disease with a complex etiology and a tendency for recurrence.So far,the clinical efficacy of western medicine in treating UC has been poor and is often accompanied by adverse reactions.Therefore,the multi-target,multi-level,synergistic,and heterogeneous characteristics of traditional Chinese medicine(TCM)are more beneficial for the treatment of UC.As one of the largest microbiotas,the intestinal flora is closely related to human health and disease.Once the intestinal flora becomes dysfunctional,it can affect the integrity of the intestinal mucosal barrier,thereby exacerbating UC.Additionally,the abnormal activation of signaling pathways may lead to dysregulation of the inflammatory response and play an important role in the pathogenesis of UC.Many studies have shown that individual TCMs and their compounds can further protect the intestinal barrier and immune system function by regulating the intestinal flora and associated signaling pathways,achieving therapeutic effects for UC.This paper summarizes the latest research results in China and abroad on the regulation of intestinal flora and related signaling pathways by individual TCMs and compounds in the treatment of UC,aiming to provide theoretical references for the clinical practice of TCM in treating UC and for related new drug research and development.关键词
溃疡性结肠炎/中药/肠道菌群/信号通路Key words
ulcerative colitis/traditional Chinese medicine/intestinal flora/signaling pathway引用本文复制引用
郑文心,李红,马辰,王琴,顾健..中药治疗溃疡性结肠炎的研究进展[J].中国中药杂志,2025,50(4):860-873,14.基金项目
国家自然科学基金项目(81573563,82302970) （81573563,82302970）
西南民族大学青藏高原科研团队项目(2024CXTD16) （2024CXTD16）
四川省中医药管理局科研团队项目(2023ZD05) （2023ZD05）
