中国中药杂志2025，Vol.50Issue(4)：922-933,12.DOI:10.19540/j.cnki.cjcmm.20241202.201
覆盆子化学成分、药理作用研究进展及其质量标志物预测分析
Research progress on chemical constituents,pharmacological effects of Rubi Fructus and predictive analysis of its quality markers
摘要
Abstract
Rubi Fructus has a long history of medicinal and edible use in China.It contains chemical components such as terpenes,flavonoids,phenolic acids,fatty acids,and alkaloids,and possesses various pharmacological activities,including antioxidant,anti-inflammatory,hypoglycemic,anti-tumor,anti-osteoporosis,and liver-protective effects.Rubi Fructus is widely applied in medical,health,and food fields.The quality of Rubi Fructus can directly affect the safety and effectiveness of clinical medication.Therefore,this article reviews the research progress on the chemical constituents and pharmacological effects of Rubi Fructus.Based on the concept of traditional Chinese medicine(TCM)quality markers(Q-markers),the article explores the screening and determination of Q-markers for Rubi Fructus from various aspects,including plant kinship,traditional efficacy,medicinal properties,measurability of chemical composition,different processing methods,producing areas,harvesting periods,and planting conditions.The components ellagic acid,kaempferol,quercetin,kaempferol-3-O-rutinoside,rutin,astragalin,tiliroside,and hyperoside are preliminarily proposed as Q-markers for Rubi Fructus,providing a reference for the quality control of Rubi Fructus.关键词
覆盆子/化学成分/药理作用/质量标志物Key words
Rubi Fructus/chemical constituent/pharmacological effect/quality marker引用本文复制引用
刘保松,余二伟,孙莹莹,宋耀宇,蒋可涵,宋亚刚,苗明三,彭孟凡..覆盆子化学成分、药理作用研究进展及其质量标志物预测分析[J].中国中药杂志,2025,50(4):922-933,12.基金项目
国家自然科学基金项目(82204679) （82204679）
国家药品监督管理局中药安全研究与评价重点实验室开放课题(SRETCM2024-04) （SRETCM2024-04）
河南省科技攻关项目(242102310523) （242102310523）
河南省高等学校重点科研项目(25A360001) （25A360001）
