中国中药杂志2025，Vol.50Issue(4)：934-945,12.DOI:10.19540/j.cnki.cjcmm.20241211.201
知母化学成分、药理作用研究进展及其质量标志物预测分析
Research progress on chemical constituents,pharmacological effects of Anemarrhenae Rhizoma and predictive analysis of its quality markers
摘要
Abstract
Anemarrhenae Rhizoma is bitter,sweet,and cold in nature,and has the effects of clearing heat,dispelling fire,nouris-hing Yin,and moisturizing dryness.It is associated with the lung,stomach,and kidney meridians,and is mainly distributed in the northwestern and northern regions of China.Modern research has shown that Anemarrhenae Rhizoma contains various chemical active constituents,including steroidal saponins,flavonoids,polysaccharides,lignans,volatile oils,and alkaloids.These constituents exhibit pharmacological effects such as anti-tumor,hypoglycemic,anti-inflammatory,and neuroprotective activities.However,there have been few comprehensive summaries of Anemarrhenae Rhizoma in recent years,which has limited its in-depth research and development.The complexity of traditional Chinese medicine constituents,along with their quality and efficacy,is easily influenced by processing,prepa-ration,and the growing environment and resource distribution.This paper summarizes the resources,chemical constituents,and phar-macological effects of Anemarrhenae Rhizoma,and predicts its quality markers(Q-markers)from several aspects,including the speci-ficity of chemical composition,properties related to preparation and active ingredients,measurability of chemical components,com-pounding environment,construction of the ″active ingredient-target″ network pathway,and differences in active ingredient content from different origins and parts.These predicted Q-markers may provide a basis for improving the quality evaluation system of Anemarrhenae Rhizoma.关键词
知母/化学成分/药理作用/复方配伍/质量标志物Key words
Anemarrhenae Rhizoma/chemical constituent/pharmacological effect/compound prescription/quality marker引用本文复制引用
王文君,杨泽敏,刘安,邵立东,程锦堂..知母化学成分、药理作用研究进展及其质量标志物预测分析[J].中国中药杂志,2025,50(4):934-945,12.基金项目
国家自然科学基金项目(82374022) （82374022）
中国中医科学院科技创新工程项目(CI2023E002,CI2021A04409) （CI2023E002,CI2021A04409）
中央级公益性科研院所基本科研业务费专项(ZZ13-YQ-061,ZXKT22012,ZXKT22039) （ZZ13-YQ-061,ZXKT22012,ZXKT22039）
