中国卒中杂志2025，Vol.20Issue(2)：163-170,8.DOI:10.3969/j.issn.1673-5765.2025.02.006
炎症标志物动态变化对急性缺血性卒中患者血管内治疗预后的影响
Effects of Dynamic Changes of Inflammatory Markers on Prognosis of Patients with Acute Ischemic Stroke Undergoing Endovascular Treatment
摘要
Abstract
Objective To explore the relationship between the levels of inflammatory markers before and 24 hours after endovascular treatment(EVT)in patients with acute ischemic stroke with large vessel occlusion(LVO-AIS)and their dynamic changes with prognosis at 3 months. Methods This retrospective study included patients with LVO-AIS who underwent EVT at the Second Affiliated Hospital of Soochow University between April 2017 and October 2021.Based on the mRS score at 3 months post-EVT,patients were divided into two groups:the favorable prognosis group(mRS score 0-2 points)and the poor prognosis group(mRS score 3-6 points).Data on age,sex,past history,and preoperative and postoperative 24 hours inflammatory response indicators[such as neutrophil(NEUT),neutrophil to lymphocyte ratio(NLR),and systemic inflammation response index(SIRI)]were collected for both groups.The association between inflammatory markers and poor prognosis,as well as the occurrence of symptomatic intracerebral hemorrhage(sICH)was explored through logistic regression analysis. Results A total of 354 patients with LVO-AIS were included in this study,with 120(33.90％)in the favorable prognosis group and 234(66.10％)in the poor prognosis group.Multivariable logistic regression analysis revealed that NEUT(OR 1.24,95％CI 1.12-1.37,P＜0.001),NLR(OR 1.09,95％CI 1.03-1.14,P=0.001),and SIRI(OR 1.14,95％CI 1.05-1.23,P=0.002)levels 24 hours after EVT were independent risk factors for poor prognosis at 3 months.NEUT(OR 1.23,95％CI 1.11-1.36,P＜0.001),NLR(OR 1.06,95％CI 1.03-1.10,P＜0.001),SIRI(OR 1.08,95％CI 1.02-1.14,P=0.005)levels 24 hours after EVT were independent risk factors for the occurrence of sICH in patients. Conclusions The dynamic elevation of postoperative inflammatory markers NEUT,NLR,and SIRI levels may increase the risk of poor prognosis at 3 months after EVT in patients with LVO-AIS.关键词
缺血性卒中/血管内治疗/预后/炎症标志物/大血管闭塞Key words
Ischemic stroke/Endovascular treatment/Prognosis/Inflammatory marker/Large vessel occlusion分类
临床医学引用本文复制引用
王辰涛,戴婧,李瑛姿,温宇昕,董理,刘春风,刘慧慧..炎症标志物动态变化对急性缺血性卒中患者血管内治疗预后的影响[J].中国卒中杂志,2025,20(2):163-170,8.基金项目
国家自然科学基金面上项目(82071310) （82071310）
