中国卒中杂志2025，Vol.20Issue(2)：199-207,9.DOI:10.3969/j.issn.1673-5765.2025.02.010
18氟代脱氧葡萄糖PET/CT评估弥漫大B细胞淋巴瘤患者动脉炎症进展的作用研究
A Study of the Role of 18F-Fluorodeoxyglucose PET/CT in Assessing the Progression of Arterial Inflammation in Patients with Diffuse Large B-Cell Lymphoma
摘要
Abstract
Objective To evaluate the changes in arterial uptake of 18F-fluorodeoxyglucose(18F-FDG)before and at mid-chemotherapy in patients with diffuse large B-cell lymphoma(DLBCL)through PET/CT,reflecting the changes in arterial inflammation during the chemotherapy process. Methods Patients with DLBCL who were diagnosed and treated at the First Affiliated Hospital of Shandong Second Medical University between January 2021 and January 2023 were retrospectively and consecutively included in the study.All patients underwent 18F-FDG PET/CT examinations before and at mid-chemotherapy.The maximum target-to-background ratio(TBRmax)and mean target-to-background ratio(TBRmean)were used to evaluate the inflammation levels in the carotid and aortic arteries before and at mid-chemotherapy.The carotid artery evaluation sites included the whole carotid artery(CA-WH)and the most-diseased segment of the carotid(CA-MDS).The aortic artery evaluation sites included the ascending aorta,aortic arch,thoracic aorta,and abdominal aorta.The differences in CA-WH-TBRmax,CA-WH-TBRmean,CA-MDS-TBRmax,and CA-MDS-TBRmean of the left and right carotid arteries in the overall patients before and at mid-chemotherapy,as well as the differences in TBRmax and TBRmean of various parts of the aorta,were compared,respectively.Based on the results of ultrasonic examinations of carotid atherosclerotic plaques,patients were classified into three groups:the unstable plaque group,the stable plaque group,and the no plaque group.The changes in target-to-background ratio(△TBR)(mid-chemotherapy TBR-pre-chemotherapy TBR)of the left and right CA-WH-TBRmax and CA-WH-TBRmean among the three groups were compared respectively to evaluate the differences in the degree of carotid inflammation changes during chemotherapy. Results A total of 85 patients with DLBCL were included in the study,including 26 patients(30.6％)in the unstable plaque group,24 patients(28.2％)in the stable plaque group,and 35 patients(41.2％)in the no plaque group.In the overall patients,the bilateral CA-WH-TBRmax(left side P=0.015,right side P=0.034),CA-MDS-TBRmax(left side P＜0.001,right side P=0.041),CA-MDS-TBRmean(left side P=0.029,right side P=0.008),and ascending aorta TBRmax(P=0.010)were significantly higher at mid-chemotherapy than pre-chemotherapy,with statistically significant differences.In the unstable plaque group,the left CA-WH-△TBRmax value was higher than that in the no plaque group(P=0.005),with a statistically significant difference.Additionally,the left CA-WH-△TBRmean in the unstable plaque group was higher than that in both the no plaque group(P=0.003)and the stable plaque group(P=0.025),with statistically significant differences. Conclusions Chemotherapy can accelerate the progression of inflammation in bilateral carotid arteries and ascending aorta of patients with DLBCL.During the tumor follow-up,PET/CT technology can early identify the evolution of chemotherapy-related arterial inflammation,thus providing a basis for early clinical intervention in atherosclerosis.关键词
血管炎症/动脉粥样硬化/心脑血管疾病/正电子发射断层成像/脱氧葡萄糖Key words
Vascular inflammation/Atherosclerosis/Cardio-cerebrovascular disease/Positron emission tomography/Deoxyglucose分类
临床医学引用本文复制引用
范萍,李爱媛,赵喆,李现军,战同霞,谢海..18氟代脱氧葡萄糖PET/CT评估弥漫大B细胞淋巴瘤患者动脉炎症进展的作用研究[J].中国卒中杂志,2025,20(2):199-207,9.基金项目
潍坊市科技发展计划项目(医学类)(2023YX034)山东第二医科大学附属医院(教学医院)科技发展基金项目(2024FYM017) （医学类）
