Abstract
Objective To systematically analyze the related factors of frailty in Chinese stroke patients,providing references for identifying the risk of frailty in stroke patients.
Methods Computer searches were conducted on cohort studies,case-control studies,and cross-sectional studies related to frailty in Chinese stroke patients from CNKI,Wanfang,VIP,Chinese Biomedical Literature Service System,Web of Science,Pubmed,Cochrane Library,and Embase.The search period was from the establishment of these databases until June 30,2024.Two researchers independently conducted literature screening,quality evaluation,and data extraction based on inclusion and exclusion criteria.Stata 15.0 statistical software was used to conduct a meta-analysis on the possible factors influencing frailty.
Results A total of 16 studies were finally included,with a total sample size of 3857 cases.Meta-analysis showed that the influencing factors of frailty in stroke patients include aging(OR 1.07,95％CI 1.02-1.11,P=0.002),age＞75 years(OR 2.89,95％CI 1.76-4.74,P＜0.001),admission NIHSS score＞14 points(OR 4.61,95％CI 2.04-10.42,P＜0.001),malnutrition(OR 3.14,95％CI 1.04-9.50,P=0.043),depression(OR 4.15,95％CI 1.95-8.85,P＜0.001),diabetes mellitus(OR 3.27,95％CI 1.76-6.08,P＜0.001),impaired activity of daily living(OR 2.37,95％CI 1.22-4.61,P=0.011),and normal activity of daily living(OR 0.96,95％CI 0.95-0.97,P＜0.001).
Conclusions There are many factors related to the frailty of stroke patients in China.Among them,normal activity of daily living is a protective factor for frailty,while aging,high admission NIHSS score,malnutrition,depression,diabetes mellitus,and impaired activity of daily living are risk factors for frailty.关键词
衰弱/卒中/中国/影响因素/系统分析Key words
Frailty/Stroke/China/Influencing factor/Meta-analysis分类
临床医学
