首页|期刊导航|中华医学杂志（英文版）|Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K-AKT signaling in rheumatoid arthritis

Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K-AKT signaling in rheumatoid arthritis

Tingting Liu Wenjing Zhou Chao Tan Xianli Wang Wei Wei Chao Jin Jing Sun Lina Zhu Chun Wang Feng Xiao Xiaochang Liu Liying Lv Xiaoke Yang

中华医学杂志（英文版）2025，Vol.138Issue(4)：441-451,11.

中华医学杂志（英文版）2025，Vol.138Issue(4)：441-451,11.DOI:10.1097/CM9.0000000000003165

Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K-AKT signaling in rheumatoid arthritis

Tingting Liu ¹Wenjing Zhou ¹Chao Tan ¹Xianli Wang ²Wei Wei ³Chao Jin ⁴Jing Sun ¹Lina Zhu ⁵Chun Wang ³Feng Xiao ³Xiaochang Liu ⁶Liying Lv ⁷Xiaoke Yang⁸

作者信息

1. Department of Pharmacy,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China||The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine,Hefei,Anhui 230022,China
2. Department of Pharmacy,The Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200090,China
3. Institute of Clinical Pharmacology,Anhui Medical University,The Key Laboratory of Anti-inflammatory and Immune Medicine,Ministry of Education,Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine,Hefei,Anhui 230032,China
4. Department of Pharmacy,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou,Zhejiang 310016,China
5. Department of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China
6. Department of Gastroenterology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China
7. Department of Clinical Laboratory,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China
8. Department of Rheumatology and Immunology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China
折叠

摘要

关键词

G protein-coupled receptor kinase 2/Paroxetine/Dendritic cell/T lymphocyte/PI3K-AKT-mTOR axis/Rheumatoid arthritis

Key words

G protein-coupled receptor kinase 2/Paroxetine/Dendritic cell/T lymphocyte/PI3K-AKT-mTOR axis/Rheumatoid arthritis

引用本文复制引用

Tingting Liu,Wenjing Zhou,Chao Tan,Xianli Wang,Wei Wei,Chao Jin,Jing Sun,Lina Zhu,Chun Wang,Feng Xiao,Xiaochang Liu,Liying Lv,Xiaoke Yang..Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K-AKT signaling in rheumatoid arthritis[J].中华医学杂志（英文版）,2025,138(4):441-451,11.

基金项目

This work was supported by the National Natural Science Foundation of China(No.81903622),the Natural Science Foundation of Universities of Anhui Province(No.2023AH053290),the Research Fund of Anhui Institute of Translational Medicine(No.2022zhyx-C30),the Open Fund of Key Laboratory of Anti-inflammatory and Immune Medicine,Ministry of Education,P.R.China(Anhui Medical University)(No.KFJJ-2023-03),the Phar-maceutical Innovation Fund of Anhui Medical University(No.YXCX202205),the Nature Science Foundation of Anhui Province of China(No.1908085QH378),the Postgraduate Innovation Research and Practice Program of Anhui Medical University(No.YJS20230060),and the Special Clinical Research Project of Shanghai Municipal Health Commission(No.202140065). （No.81903622）

中华医学杂志（英文版）

ISSN：0366-6999

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